c-JUN Antibody – Rabbit Polyclonal

The products of the proto-oncogenes c-Jun (c-Jun was previously known as the Fos-binding protein p39) and c-Fos are known to form a complex in the nucleus (2, 6). AP-1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site (1). There is evidence that AP-1 proteins, mostly those that belong to the Jun group, control cell life and death through their ability to regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16 (3). The Fos and Jun proto-oncogenes expression is induced transiently by a great variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons (5). Studies have established a unique role for Fos in determining the differentiation and activity of progenitors of the osteoclast lineage (4). c-Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of c-Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of c-Jun probably results from transcriptional deregulation of v-Jun-responsive target genes (7).

1.) Himes SR, Sester DP, Ravasi T, Cronau SL, Sasmono T, Hume DA. 2006. The JNK are important for development and survival of macrophages. J Immunol. Feb 15;176(4):2219-28.2.) Dann SG, Ted Allison W, Veldhoen K, Johnson T, Hawryshyn CW. 2004. Chromatin immunoprecipitation assay on the rainbow trout opsin proximal promoters illustrates binding of NF-kappaB and c-jun to the SWS1 promoter in the retina. Exp Eye Res. May;78(5):1015-24.

1. Karin M, Liu Zg, Zandi E. AP-1 function and regulation.Curr Opin Cell Biol. 1997 Apr;9(2):240-6.2. Bos TJ, Rauscher FJ 3rd, Curran T, Vogt PK. The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein. Oncogene. 1989 Feb;4(2):123-6.3. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene. 2001 Apr 30;20(19):2390-400.4. Liebermann DA, Gregory B, Hoffman B. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int J Oncol. 1998 Mar;12(3):685-7005. Curran T. Fos and Jun: oncogenic transcription factors.Tohoku J Exp Med. 1992 Oct;168(2):169-74.6. Rauscher FJ 3rd, Voulalas PJ, Franza BR Jr, Curran T. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev. 1988 Dec;2(12B):1687-99.7. Fu Sl, Bottoli I, Goller M, Vogt PK. Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation.. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5716-21.

Small volumes of anti-c-Jun antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS440024 is an antibody targeting c-Jun. Also known as c-Jun (A15) Antibody. Reactive in Mouse, rat, human. Host: Rabbit.