HspBP1 Antibody – Rabbit Polyclonal

HspBP1 is an Hsp70-interacting protein that was first isolated from a human heart cDNA library using the yeast two-hybrid system (1). The ATPase domain of Hsp70 binds HspBP1 and upon binding inhibits Hsp70 chaperone activity. More recently HspBP1 was found to be a homologue of the yeast Fes1 and Sls1 proteins and promotes nucleotide dissociation from Hsc70. HspBP1 has also been shown to strip nucleotide from yeast Ssa1p, making it a member of the class of nucleotide exchange factors that exhibit varying degrees of compartment and species specificity (2). HspBP1 is highly expressed in heart, brain, skeletal muscle, and pancreas tissues. It is also expressed in pancreatic, hepatic, and astrocytic cell lines.

1.) Alberti S, Bohse K, Arndt V, Schmitz A, Hohfeld J. 2004. The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell. 2004 Sep;15(9):4003-10. 2.) Raynes DA, Thomson CA, Stroster J, Newton T, Cuneo P, Guerriero V. 2006. Human serum contains detectable levels of the Hsp70 cochaperone HspBP1 and antibodies bound to HspBP1. J Immunoassay Immunochem. 27(3):251-64.

1. Raynes DA, Guerriero V Jr. 1998. Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein. J. Biol Chem. 273(49):32883-32888.2. Kabani M, McLellan C, Raynes DA, Guerriero V, Brodsky JL. 2002. HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an Hsc-70 nucleotide exchange factor. FEBS Lett. 531(2):339-342.3. McLellan CA, Raynes DA, Guerriero V. 2003. HspBP1, an Hsp70 cochaperone, has two structural domains and is capable of altering the conformation of the Hsp70 ATPase domain. J. Biol. Chem. 278(21):19017-19022.

Small volumes of anti-HspBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS440079 is an antibody targeting HspBP1. Also known as HspBP1 (FL4) Antibody. Reactive in Human. Host: Rabbit.