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MARCH4 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS004423

MBS004423 is an antibody targeting MARCH4. Also known as Rabbit MARCH4 Antibody. Reactive in Human, mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MARCH4, Antibody
Full Product Name
Rabbit MARCH4 Antibody
Product Gene Name
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Molecular Weight
45,528 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (217122585..217236750, complement). Location: 2q35
OMIM
608208
3D Structure
ModBase 3D Structure for Q9P2E8
Applications Tested/Suitable for anti-MARCH4 antibody
Immunohistochemistry (IHC), ELISA (EIA)

Other Notes

Small volumes of anti-MARCH4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MARCH4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
E3 ubiquitin-protein ligase MARCH4
NCBI Official Synonym Full Names
membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
NCBI Official Symbol
MARCH4
NCBI Official Synonym Symbols
RNF174; MARCH-IV
UniProt Protein Name
E3 ubiquitin-protein ligase MARCH4
UniProt Synonym Protein Names
Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; MARCH-IV; RING finger protein 174
UniProt Gene Name
MARCH4
UniProt Synonym Gene Names
KIAA1399; RNF174; MARCH-IV
UniProt Entry Name
MARH4_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase MARCH4; RING finger protein 174; membrane-associated RING-CH protein IV; membrane-associated RING finger protein 4

NCBI Summary for MARCH4

MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
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UniProt Comments for MARCH4

MARCH4: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein type: Ligase; Membrane protein, integral; EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19; Membrane protein, multi-pass; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: Golgi membrane; Golgi stack; integral to membrane; trans-Golgi network

Molecular Function: zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: protein ubiquitination
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-MARCH4 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with MARCH4 and Liver
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