Human CCL14 Active Protein – Cat# MBS444012

CCL14 Human Active Protein

Name: CCL14 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS444012
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS444012

Hemofiltrate CC chemokine-1(HCC-1/CCL14) is endogeneously expressed by numerous tissues. Upon processing of the N terminal residues of the full length HCC-1 by the uPA-plasmin system, the active form of HCC-1 (made by ChemoTactics) is a strong agonist for… More details

$220 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCL14, Active Protein

Full Product Name

Human CCL14 (HCC-1)

Product Gene Name

CCL14 active protein

Product Synonym Names

CCL14 (HCC-1) Biotin

Sequence

GPYHPSECCF TYTTYKIPRQ RIMDYYETNS QCSKPGIVFI TKRGHSVCTN PSDKWVQD YIKDMKEN

Host

E Coli derived

Form/Format

Lyophilized

Purity/Purification

> 97% by SDS PAGE

Preparation and Storage

Avoid repeated freeze-thaw cycles
12 months from date of receipt, -20 to -70 degree C as supplied.
1 month, 2 to 8 degree C under sterile conditions after reconstitution.
3 months, -20 to -70 degree C under sterile conditions after reconstitution.

Matching Pairs

Unconjugated Antibody: CCL14 (MBS444020)
Biotin Conjugated Antibody: CCL14 (MBS444012)

Molecular Weight

Actual Molecular Mass: Mass spec data confirmed the expected mass of 7.801 kDa
Predicted Molecular Mass: 7.801 kDa

Sequence Positions

28-93

3D Structure

ModBase 3D Structure for P16627

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Reconstitution

Spin sample prior to reconstitution. Recommended at 100mug/mL in sterile water

Carrier Protein

None

Activity

EC50 = 0.1-0.4 nM determined by Migration Assay with cells expressing recombinant CCR1

Extinction Coefficient

13,850 M-1 cm-1

Endotoxin Level

<0.01 EU per 1mug of the protein by the LAL method

Modification

None

UNSPSC Code

12352202

Product References and Citations for CCL14 active protein

1. "HCC-1, a novel chemokine from human plasma" Schulz-Knappe P., Mägert H., Dewald B., J Exp Med 183:295-299 (1996)
2. "Urokinase Plasminogen Activator and Plasmin Efficiently Convert Hemofiltrate CC Chemokine 1 into Its Active [9-74] Processed Variant" Vakili J., Standker L., Detheux M., Vassart, G., Forssmann W., Parmentier M. J Immunol 167:3406-3413 (2001)

Other Notes

Small volumes of CCL14 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL14 purchase

MBS444012 is an active protein targeting CCL14. Also known as Human CCL14 (HCC-1). Host: E Coli derived.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL14. It may not necessarily be applicable to this product.

NCBI GI #

124339838

NCBI GeneID

15482

NCBI Accession #

NP_038586.2

UniProt Primary Accession #

P16627

UniProt Secondary Accession #

O88686; Q61693

UniProt Related Accession #

P16627

GenBank Nucleotide #

NM_013558.2

NCBI Official Full Name

heat shock 70 kDa protein 1-like

NCBI Official Synonym Full Names

heat shock protein 1-like

NCBI Official Symbol

Hspa1l

NCBI Official Synonym Symbols

Msh5; Hsc70t

UniProt Protein Name

Heat shock 70 kDa protein 1-like

UniProt Synonym Protein Names

Heat shock 70 kDa-like protein 1; Spermatid-specific heat shock protein 70

Protein Family

C-C motif chemokine

UniProt Gene Name

Hspa1l

UniProt Synonym Gene Names

Hsc70t; Heat shock 70 kDa protein 1L

UniProt Entry Name

HS71L_MOUSE

NCBI Protein Information

heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1L; heat shock 70 kDa-like protein 1; heat shock 70kDa protein 1-like; heat shock protein cognate 70, testis; heat shock-related protein hsc70t; inducible heat shock protein 70; spermatid-specific heat shock protein 70

UniProt Comments for CCL14

HSPA1L: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Not induced by heat shock. Expressed in spermatids. Belongs to the heat shock protein 70 family.

Protein type: Heat shock protein; Chaperone; Mitochondrial

Cellular Component: signalosome; cytosol

Molecular Function: unfolded protein binding; nucleotide binding; ATP binding

Biological Process: binding of sperm to zona pellucida; multicellular organismal development; spermatogenesis; protein refolding; cell differentiation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL14 active protein

Reference Product	PubMed Publications
Hsf1 active protein	>1 publications with CCL14 and Hsf1
Hsp90ab1 active protein	>1 publications with CCL14 and Hsp90ab1
Hsp90aa1 active protein	>1 publications with CCL14 and Hsp90aa1

Pathways associated with CCL14 active protein

Products by Pathway	Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Estrogen Signaling Pathway antibodies	Estrogen Signaling Pathway Diagram
Estrogen Signaling Pathway antibodies	Estrogen Signaling Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram

Diseases associated with CCL14 active protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>7 publications with CCL14 and Immune System Diseases
Cardiovascular Diseases Antibodies	>6 publications with CCL14 and Cardiovascular Diseases
Necrosis Antibodies	>6 publications with CCL14 and Necrosis
Inflammation Antibodies	>4 publications with CCL14 and Inflammation
Lung Diseases Antibodies	>3 publications with CCL14 and Lung Diseases
Drug-Related Side Effects and Adverse Reactions Antibodies	>3 publications with CCL14 and Drug-Related Side Effects and Adverse Reactions
Carcinoma, Hepatocellular Antibodies	>3 publications with CCL14 and Carcinoma, Hepatocellular
Drug Hypersensitivity Antibodies	>3 publications with CCL14 and Drug Hypersensitivity
Nervous System Diseases Antibodies	>2 publications with CCL14 and Nervous System Diseases
Heart Diseases Antibodies	>2 publications with CCL14 and Heart Diseases

Organs/Tissues associated with CCL14 active protein

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>3 publications with CCL14 and Testis
Embryonic Tissue Antibodies	>2 publications with CCL14 and Embryonic Tissue
Brain Antibodies	>1 publications with CCL14 and Brain
Eye Antibodies	>1 publications with CCL14 and Eye