Rabbit Anti-STAT6 (pY641) Antibody – Cat# MBS462172

STAT6 (pY641) Antibody – Rabbit

Name: STAT6 (pY641) Antibody; Rabbit; Human/Rat/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS462172
Price: 355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS462172

STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a ligand binding to its cell surface receptor. Activation by phosphorylation of STAT6 at tyrosine 641 upon… More details

$355 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

STAT6 (pY641), Antibody

Full Product Name

Rabbit anti Phospho- STAT6 (pTyr 641)

Product Gene Name

anti-STAT6 (pY641) antibody

Product Synonym Names

Rabbit anti-Phospho-STAT6 (pY641); Signal transducer and activator of transcription 6 (STAT6); IL-4-STAT

Host

Rabbit

Species Reactivity

Human, Rat, Mouse,

Form/Format

This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer

Purity/Purification

The Rabbit IgG is purified by site-modified Epitope Affinity Purification.

Concentration

Size: 100 ug/200 ul (lot specific)

Specificity

This antibody recognizes STAT6 (pY641) with a phosphorylated sites of Tyr641. It does not cross-react with non-phosphospecific peptide.

Preparation and Storage

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Molecular Weight

95 kDa

Chromosome Location

Chromosome: 12; NC_000012.11 (57489187..57505196, complement). Location: 12q13

OMIM

601512

3D Structure

ModBase 3D Structure for P42226

Antigen Preparation

A synthetic peptide surrounding to the epitope -RGYVP-- with phosphorylation sites at Tyr641 of STAT6 protein from human, mouse and rat origins.

Positive Control

HepG2

Cellular Location

Nuclear

Applications Tested/Suitable for anti-STAT6 (pY641) antibody

ELISA, Western Blot, Immunohistochemistry

Application Notes for anti-STAT6 (pY641) antibody

Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 1:100 ug/ml

Product References and Citations for anti-STAT6 (pY641) antibody

Zhiguang Li et al (2008). Endogenous Interleukin-4 Promotes Tumor Development by Increasing Tumor Cell Resistance to Apoptosis. Cancer Research 68, 8687-94.

Other Notes

Small volumes of anti-STAT6 (pY641) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STAT6 (pY641) purchase

MBS462172 is an antibody targeting STAT6 (pY641). Also known as Rabbit anti Phospho- STAT6 (pTyr 641). Reactive in Human, Rat, Mouse,. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT6 (pY641). It may not necessarily be applicable to this product.

NCBI GI #

23397678

NCBI GeneID

6778

NCBI Accession #

NP_003144.3

UniProt Primary Accession #

P42226

UniProt Secondary Accession #

Q5FBW5; Q71UP4; A8K316

UniProt Related Accession #

P42226; Q56TK0; Q5FBW6; Q6LCD8; Q9BQD2

GenBank Nucleotide #

NM_003153.4

NCBI Official Full Name

signal transducer and activator of transcription 6 isoform 1

NCBI Official Synonym Full Names

signal transducer and activator of transcription 6, interleukin-4 induced

NCBI Official Symbol

STAT6

NCBI Official Synonym Symbols

STAT6B; STAT6C; D12S1644; IL-4-STAT

UniProt Protein Name

Signal transducer and activator of transcription 6

UniProt Synonym Protein Names

IL-4 Stat

UniProt Gene Name

STAT6

UniProt Entry Name

STAT6_HUMAN

NCBI Protein Information

signal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT

NCBI Summary for STAT6 (pY641)

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

UniProt Comments for STAT6 (pY641)

Function: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

Subunit structure: Forms a homodimer or a heterodimer with a related family member

By similarity. Interacts with NCOA1 via its C-terminal LXXLL motif. Ref.7

Subcellular location: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation.

Post-translational modification: Tyrosine phosphorylated following stimulation by IL-4 and IL-3

Sequence similarities: Belongs to the transcription factor STAT family.Contains 1 SH2 domain.

Research Articles on STAT6 (pY641)

1. These regulatory polymorphisms in the promoter regions of STAT6 may assist in identifying potential targets for the therapeutic control of gene expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STAT6 (pY641) antibody

Reference Product	PubMed Publications
JAK1 antibody	>107 publications with STAT6 (pY641) and JAK1
STAT2 antibody	>48 publications with STAT6 (pY641) and STAT2

Pathways associated with anti-STAT6 (pY641) antibody

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Down-stream Signal Transduction Pathway antibodies	Down-stream Signal Transduction Pathway Diagram
IL-3 Signaling Pathway antibodies	IL-3 Signaling Pathway Diagram
IL-4 Signaling Pathway antibodies	IL-4 Signaling Pathway Diagram
IL12-mediated Signaling Events Pathway antibodies	IL12-mediated Signaling Events Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Signaling By PDGF Pathway antibodies	Signaling By PDGF Pathway Diagram
Signaling Events Mediated By TCPTP Pathway antibodies	Signaling Events Mediated By TCPTP Pathway Diagram

Diseases associated with anti-STAT6 (pY641) antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>293 publications with STAT6 (pY641) and Inflammation
Asthma Antibodies	>247 publications with STAT6 (pY641) and Asthma
Neoplasms Antibodies	>166 publications with STAT6 (pY641) and Neoplasms
Respiratory Hypersensitivity Antibodies	>166 publications with STAT6 (pY641) and Respiratory Hypersensitivity
Intestinal Diseases Antibodies	>51 publications with STAT6 (pY641) and Intestinal Diseases
Fibrosis Antibodies	>48 publications with STAT6 (pY641) and Fibrosis
Dermatitis, Atopic Antibodies	>40 publications with STAT6 (pY641) and Dermatitis, Atopic
Carcinoma Antibodies	>40 publications with STAT6 (pY641) and Carcinoma
Leukemia Antibodies	>36 publications with STAT6 (pY641) and Leukemia
Neoplasms, Experimental Antibodies	>30 publications with STAT6 (pY641) and Neoplasms, Experimental

Organs/Tissues associated with anti-STAT6 (pY641) antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>848 publications with STAT6 (pY641) and Blood
Lung Antibodies	>224 publications with STAT6 (pY641) and Lung
Bone Antibodies	>92 publications with STAT6 (pY641) and Bone
Spleen Antibodies	>89 publications with STAT6 (pY641) and Spleen
Bone Marrow Antibodies	>81 publications with STAT6 (pY641) and Bone Marrow
Muscle Antibodies	>79 publications with STAT6 (pY641) and Muscle
Intestine Antibodies	>67 publications with STAT6 (pY641) and Intestine
Skin Antibodies	>62 publications with STAT6 (pY641) and Skin
Liver Antibodies	>62 publications with STAT6 (pY641) and Liver
Lymph Node Antibodies	>58 publications with STAT6 (pY641) and Lymph Node