Paxillin (Ser-83) (PXN) Antibody – Rabbit Polyclonal

Paxillin, a focal adhesion protein, is involved in focal adhesion formationduring cell adhesion and migration. Paxillin contains LD motifs, LIMdomains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Serine phosphorylation of paxillin occurs in response to growth-factor activation and fibronectins. Both ERK and p38MAPK kinases phosphorylate serine 83 in vitro. HGF stimulation of murine epithelial cells leads to ERK-mediated phosphorylation of Ser-83, which is required for HGF-induced cell spreading and migration. In addition, Ser -83 is phosphorylated in response to NGF in PC12 cells, and this phosphorylation may be involved in neurite extension. In human paxillin, Ser-85 rather than Ser-83 may be the site phosphorylated by p38 MAPK and mutation of this site inhibits NGF-induced neurite extension. Thus, serine residues in the N-terminal region of paxillin may be important for growth-factor mediated changes in activity.

• Huang, C. et al. (2004) J Cell Biol. 164(4):593-602.
• Ishibe, S. et al. (2004) Mol. Cell 16 :257-267.

Small volumes of anti-Pxn antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS472048 is an antibody targeting Pxn. Also known as Paxillin (Ser-83), phospho-specific. Reactive in Rat, Mouse. Host: Rabbit.