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Plexin A1 (Sema Domain) (PLXNA1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS472055

Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-related sequences. The cytoplasmic… More details

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Product Overview

Online Datasheet in PDF
Product Name
Plexin A1 (Sema Domain) (PLXNA1), Polyclonal Antibody
Full Product Name
Plexin A1 (Sema Domain)
Product Gene Name
anti-PLXNA1 antibody
Product Synonym Names
PLXN1; NOV
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat, Mouse
Form/Format
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ml phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
Purity/Purification
Affinity Purified
Specificity
The antibody detects a 220 kDa* protein corresponding to the apparent molecular mass of Plexin-A1 on SDS-PAGE immunoblots of adult mouse brain and Cos-7 cells transfected with mouse Plexin-A1. In immunocytochemistry, this antibody co-localizes with anti-Myc in Cos-7 cells transfected with Myc-tagged mouse Plexin-A1.
Preparation and Storage
Store at -20 degree C. Do not aliquot. Stable for 1 year.
Molecular Weight
208419 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (126707437..126756235). Location: 3q21.3
OMIM
601055
3D Structure
ModBase 3D Structure for Q6ZTY7
Immunogen
Plexin-A1 synthetic peptide (coupled to carrier protein) corresponding to a region within the semaphorin domain in human Plexin-A1. This sequence is highly conserved in rat and mouse Plexin-A1, and has low homology to other Plexin family members.
Applications Tested/Suitable for anti-PLXNA1 antibody
ELISA, Western Blot, Immunocytochemistry
Application Notes for anti-PLXNA1 antibody
ELISA: 1:2000
Immunocytochemistry: 1:50
Western Blot: 1:500

Testing Data of anti-PLXNA1 antibody

Rabbit Anti-PLXNA1 Polyclonal Antibody – Cat# MBS472055

Testing Data 2 of anti-PLXNA1 antibody

Rabbit Anti-PLXNA1 Polyclonal Antibody, Testing Data 2 – Cat# MBS472055

Product References and Citations for anti-PLXNA1 antibody

• Takahashi, T. & Strittmatter, S.M. (2001) Neuron 29:429
• Tamagnone, L. et al. (1999) Cell 99:71.

Other Notes

Small volumes of anti-PLXNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLXNA1 purchase

MBS472055 is an antibody targeting PLXNA1. Also known as Plexin A1 (Sema Domain). Reactive in Human, Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLXNA1. It may not necessarily be applicable to this product.

NCBI GI #
49355818
NCBI GeneID
5361
NCBI Accession #
NP_115618.2
UniProt Primary Accession #
Q6ZTY7
UniProt Related Accession #
Q6ZTY7; Q9NSM6; Q9UIW2
GenBank Nucleotide #
NM_032242.2
NCBI Official Full Name
plexin A1
NCBI Official Synonym Full Names
plexin A1
NCBI Official Symbol
PLXNA1
NCBI Official Synonym Symbols
NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121
UniProt Protein Name
cDNA FLJ44113 fis, clone TESTI4046487, highly similar to Mus musculus plexin A1 (Plxna1)
Protein Family
Plexin
UniProt Entry Name
Q6ZTY7_HUMAN
NCBI Protein Information
plexin-A1; plexin 1; OTTHUMP00000215966; semaphorin receptor NOV

UniProt Comments for PLXNA1

PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytoplasm; integral to membrane; plasma membrane; nucleus

Molecular Function: semaphorin receptor activity; receptor activity

Biological Process: axon guidance; regulation of smooth muscle cell migration; multicellular organismal development
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Research Articles on PLXNA1

1. Expression of Plexin A1 in gastric carcinoma was significantly higher than that in normal gastric mucosa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLXNA1 antibody

 Reference Product  PubMed Publications
 PLXNB1 antibody  >10 publications with PLXNA1 and PLXNB1
 SEMA6D antibody  >9 publications with PLXNA1 and SEMA6D
 NRP1 antibody  >4 publications with PLXNA1 and NRP1
 RND1 antibody  >2 publications with PLXNA1 and RND1
 FES antibody  >2 publications with PLXNA1 and FES
 RHOD antibody  >1 publications with PLXNA1 and RHOD

Pathways associated with anti-PLXNA1 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway antibodies  SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway Diagram
 Sema3A PAK Dependent Axon Repulsion Pathway antibodies  Sema3A PAK Dependent Axon Repulsion Pathway Diagram
 Sema3A PAK Dependent Axon Repulsion Pathway antibodies  Sema3A PAK Dependent Axon Repulsion Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-PLXNA1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with PLXNA1 and Kidney Diseases
 Adenoma Antibodies  >1 publications with PLXNA1 and Adenoma
 Neurodegenerative Diseases Antibodies  >1 publications with PLXNA1 and Neurodegenerative Diseases
 Kidney Neoplasms Antibodies  >1 publications with PLXNA1 and Kidney Neoplasms
 Diabetes Mellitus Antibodies  >1 publications with PLXNA1 and Diabetes Mellitus

Organs/Tissues associated with anti-PLXNA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with PLXNA1 and Brain
 Embryonic Tissue Antibodies  >14 publications with PLXNA1 and Embryonic Tissue
 Blood Antibodies  >10 publications with PLXNA1 and Blood
 Vascular Antibodies  >9 publications with PLXNA1 and Vascular
 Eye Antibodies  >5 publications with PLXNA1 and Eye
 Kidney Antibodies  >5 publications with PLXNA1 and Kidney
 Heart Antibodies  >4 publications with PLXNA1 and Heart
 Bone Antibodies  >3 publications with PLXNA1 and Bone
 Lung Antibodies  >3 publications with PLXNA1 and Lung
 Skin Antibodies  >2 publications with PLXNA1 and Skin
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