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FYB Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475283

Entrez Summary: The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells.The encoded protein is involved in platelet activation and controls the expression of interleukin-2.Three transcript variants encoding… More details

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Product Overview

Online Datasheet in PDF
Product Name
FYB, Monoclonal Antibody
Full Product Name
Anti-FYB Mouse mAb
Product Gene Name
Product Synonym Gene Name
ADAP; PRO0823; SLAP-130.
Product Synonym Names
ADAP; Adhesion and degranulation promoting adaptor protein; FYB 120/130; Fyb; FYB-120/130; FYB_HUMAN; FYN binding protein; FYN T binding protein; FYN-binding protein; FYN-T-binding protein; p120/p130; PRO0823; SLAP 130; SLAP-130; SLAP130; SLP 76 associated phosphoprotein; SLP-76-associated phosphoprotein; SLP76 associated phosphoprotein
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2H9-H6-G10
Host
Mouse
Source: Human
Species Reactivity
Human
Sensitivity
This antibody detects endogenous levels of FYB and does not cross-react with related proteins.
Form/Format
Ascites containing with 0.02% sodium azide and 50% glycerol.
Molecular Weight
120
OMIM
AF001862 mRNA
3D Structure
ModBase 3D Structure for O15117
Immunogen
Purified recombinant human FYB protein fragments expressed in E Coli.
Sequence Similarities
Contains 1 SH3 domain.
Subunit Structure
Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 By similarity. Interacts with FYN, LCP2, SKAP1 and SKAP2. Interacts with FASLG. Interacts with EVL.
Subcellular Location
Cytoplasm. Nucleus
Applications Tested/Suitable for anti-FYB antibody
Western Blot (WB)
Application Notes for anti-FYB antibody
WB: 1:500

Western Blot (WB) of anti-FYB antibody

Western blot detection of FYB in 10, 20 and 30ug Jurkat cell lysate using FYB mouse mAb (1:500 diluted).Predicted band size:120KDa.Observed band size:120KDa.
Mouse Anti-FYB Monoclonal Antibody – Cat# MBS475283

Other Notes

Small volumes of anti-FYB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FYB purchase

MBS475283 is an antibody targeting FYB. Also known as Anti-FYB Mouse mAb. Reactive in Human. Host: Mouse
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for FYB. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
FYN-binding protein isoform 3
NCBI Official Synonym Full Names
FYN binding protein
NCBI Official Symbol
FYB
NCBI Official Synonym Symbols
ADAP; PRO0823; SLAP130; SLAP-130
UniProt Protein Name
FYN-binding protein
UniProt Synonym Protein Names
Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein
Protein Family
UniProt Gene Name
FYB
UniProt Synonym Gene Names
SLAP130; ADAP; p120/p130
NCBI Protein Information
FYN-binding protein

NCBI Summary for FYB

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
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UniProt Comments for FYB

SLAP-130: an adapter protein for fyn and the SH2-domain-containing leucocyte protein-76 (SLP76) in T cells. T-cell receptor ligation leads to increased tyrosine phosphorylation of SLAP-130. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: actin cytoskeleton; cytosol; plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: NLS-bearing substrate import into nucleus; protein amino acid phosphorylation; signal transduction; T cell receptor signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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