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Anthrax Protective Antigen (pxo1_110) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475285

Entrez Summary: The exotoxin produced by B. Anthracis is composed of three proteins: a cell-receptor binding protein known as Protective Antigen (PA), and two enzymes, Edema Factor (EF) and Lethal Factor (LF). An 83 kDa form of PA binds to a cell surface… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Anthrax Protective Antigen (pxo1_110), Monoclonal Antibody
Full Product Name
Anti-Anthrax Protective Antigen Mouse mAb
Product Gene Name
Product Synonym Names
anthrax PA; Anthrax toxins translocating protein; PA 83; PA; PA83; Pag; PagA; Protective antigen
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
5C1-C8-H8
Host
Mouse
Source: Bacillus anthracis
Species Reactivity
Bacillus anthracis
Sensitivity
This antibody detects Anthrax Protective Antigen.
Form/Format
PBS (pH 7.4) containing with 0.03% Proclin300 and 25% glycerol.
Purity/Purification
Affinity Purified
Concentration
4.0mg/mL (lot specific)
Molecular Weight
86
3D Structure
ModBase 3D Structure for P13423
Sequence Similarities
Belongs to the bacterial binary toxin family.
Subunit Structure
Anthrax toxins are composed of three distinct proteins, a protective antigen (PA), a lethal factor (LF) and an edema factor (EF). None of these is toxic by itself. PA LF forms the lethal toxin (LeTx); PA EF forms the edema toxin (EdTx). PA-63 forms heptamers and this oligomerization is required for LF or EF binding. This complex is endocytosed by the host. Once activated, at low pH, the heptamer undergoes conformational changes and converts from prepore to pore inserted in the membrane, forming cation-selective channels and triggering the release of LF and EF in the host cytoplasm.
Subcellular Location
Secreted; extracellular space
Applications Tested/Suitable for anti-pxo1_110 antibody
ELISA (EIA)

Testing Data of anti-pxo1_110 antibody

Standard Curve for Anthrax Protective Antigen: Capture Antibody Mouse mAb 201240 to Anthrax Protective Antigen at 4mug/ml and other antibody for detecting.
Mouse Anti-pxo1_110 Monoclonal Antibody – Cat# MBS475285

Other Notes

Small volumes of anti-pxo1_110 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for pxo1_110 purchase

MBS475285 is an antibody targeting pxo1_110. Also known as Anti-Anthrax Protective Antigen Mouse mAb. Reactive in Bacillus anthracis. Host: Mouse
Source: Bacillus anthracis.

Additional Details

NCBI/Uniprot data below describe general gene information for pxo1_110. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
pXO1-110 (plasmid)
NCBI Official Symbol
pxo1_110
UniProt Protein Name
Protective antigen
UniProt Synonym Protein Names
Anthrax toxins translocating protein; PA-83; PA83
UniProt Gene Name
pagA
UniProt Synonym Gene Names
pag; PA; PA83; PA20; PA63
NCBI Protein Information
pXO1-110

UniProt Comments for pxo1_110

One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-pxo1_110 antibody

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