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TUBB3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475942

Entrez Summary: Tubulin, beta 3, also known as TUBB3. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non exchangeable site on the alpha-chain. Tubulin is a highly… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
TUBB3, Monoclonal Antibody
Full Product Name
Anti-TUBB3 Mouse mAb
Product Gene Name
anti-TUBB3 antibody
Product Synonym Gene Name
tubulin, beta 3; MC1R; TUBB4
Product Synonym Names
tubulin, beta 3; MC1R; TUBB4
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2E9
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
50
OMIM
U47634 mRNA
3D Structure
ModBase 3D Structure for Q13509
Immunogen
Purified recombinant fragment of human TUBB3 expressed in E Coli.
Applications Tested/Suitable for anti-TUBB3 antibody
Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

Western Blot (WB) of anti-TUBB3 antibody

Western blot analysis using TUBB3 mouse mAb against HepG2 (1), A549 (2) and Hela (3) cell lysate.
Mouse Anti-TUBB3 Monoclonal Antibody – Cat# MBS475942

Immunofluorescence (IF) of anti-TUBB3 antibody

Immunofluorescence analysis of PANC-1 cells using TUBB3 mouse mAb (green). Blue
Mouse Anti-TUBB3 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS475942

Flow Cytometry (FC/FACS) of anti-TUBB3 antibody

Flow cytometric analysis of A549 cells using TUBB3 mouse mAb (green) and negative control (purple).
Mouse Anti-TUBB3 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS475942

Other Notes

Small volumes of anti-TUBB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TUBB3 purchase

MBS475942 is an antibody targeting TUBB3. Also known as Anti-TUBB3 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TUBB3. It may not necessarily be applicable to this product.

NCBI GI #
308235963
NCBI GeneID
10381
NCBI Accession #
NP_001184110.1
UniProt Primary Accession #
Q13509
UniProt Secondary Accession #
Q9BTZ0; Q9BW10; A8K854
UniProt Related Accession #
Q13509
GenBank Nucleotide #
NM_001197181.1
NCBI Official Full Name
tubulin beta-3 chain isoform 2
NCBI Official Synonym Full Names
tubulin beta 3 class III
NCBI Official Symbol
TUBB3
NCBI Official Synonym Symbols
CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A
UniProt Protein Name
Tubulin beta-3 chain
UniProt Synonym Protein Names
Tubulin beta-4 chain; Tubulin beta-III
Protein Family
Tubulin
UniProt Gene Name
TUBB3
UniProt Synonym Gene Names
TUBB4
NCBI Protein Information
tubulin beta-3 chain

NCBI Summary for TUBB3

This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
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UniProt Comments for TUBB3

TUBB3: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Dimer of alpha and beta chains. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. Belongs to the tubulin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: dendrite; microtubule; nucleus

Molecular Function: protein binding

Biological Process: axon guidance

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 1; Fibrosis Of Extraocular Muscles, Congenital, 3a, With Or Without Extraocular Involvement
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Research Articles on TUBB3

1. It findings reveal that expression of relatively low levels of TUBB3 in mitotic cells can be detrimental for their cytokinesis and underscore the importance of CIT-K in counteracting this event.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TUBB3 antibody

 Products by Pathway  Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies  Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway antibodies  Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram

Diseases associated with anti-TUBB3 antibody

 Disease Name  Pubmed Publications
 Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement Antibodies  >514 publications with TUBB3 and Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement
 Neoplasms Antibodies  >47 publications with TUBB3 and Neoplasms
 Nervous System Diseases Antibodies  >16 publications with TUBB3 and Nervous System Diseases
 Ovarian Neoplasms Antibodies  >12 publications with TUBB3 and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >9 publications with TUBB3 and Breast Neoplasms
 Fibrosis Antibodies  >8 publications with TUBB3 and Fibrosis
 Neoplasms, Experimental Antibodies  >5 publications with TUBB3 and Neoplasms, Experimental
 Brain Diseases Antibodies  >4 publications with TUBB3 and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >4 publications with TUBB3 and Carcinoma, Squamous Cell
 Eye Diseases Antibodies  >4 publications with TUBB3 and Eye Diseases

Organs/Tissues associated with anti-TUBB3 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >22 publications with TUBB3 and Lung
 Brain Antibodies  >20 publications with TUBB3 and Brain
 Nerve Antibodies  >10 publications with TUBB3 and Nerve
 Muscle Antibodies  >9 publications with TUBB3 and Muscle
 Eye Antibodies  >9 publications with TUBB3 and Eye
 Heart Antibodies  >8 publications with TUBB3 and Heart
 Embryonic Tissue Antibodies  >6 publications with TUBB3 and Embryonic Tissue
 Testis Antibodies  >4 publications with TUBB3 and Testis
 Lymph Antibodies  >3 publications with TUBB3 and Lymph
 Lymph Node Antibodies  >3 publications with TUBB3 and Lymph Node
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