CDK6 Antibody – Rabbit Polyclonal

CDK6: a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers.

Protein type: EC 2.7.11.22; Kinase, protein; Cell cycle regulation; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: nucleoplasm; ruffle; centrosome; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus; cytosol

Molecular Function: protein binding; cyclin binding; cyclin-dependent protein kinase activity; ATP binding

Biological Process: Notch signaling pathway; negative regulation of myeloid cell differentiation; dentate gyrus development; gliogenesis; response to virus; T cell differentiation in the thymus; protein amino acid phosphorylation; astrocyte development; negative regulation of cell cycle; regulation of erythrocyte differentiation; negative regulation of cell proliferation; negative regulation of cell differentiation; positive regulation of fibroblast proliferation; cell division; generation of neurons; regulation of gene expression; cell dedifferentiation; negative regulation of osteoblast differentiation; mitotic cell cycle; cell cycle arrest; positive regulation of cell-matrix adhesion; lateral ventricle development; negative regulation of epithelial cell proliferation; G1/S transition of mitotic cell cycle

Disease: Microcephaly 12, Primary, Autosomal Recessive