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CD38 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475969

Entrez Summary: CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal… More details

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Product Overview

Product Name
CD38, Monoclonal Antibody
Full Product Name
Anti-CD38 Mouse mAb
Product Gene Name
anti-CD38 antibody
Product Synonym Gene Name
T10; CD38
Product Synonym Names
T10; CD38
Clonality
Monoclonal
Isotype
IgG1
Clone Number
6E12D
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
34
OMIM
M34461 mRNA
Immunogen
Purified recombinant fragment of human CD38 expressed in E Coli.
Applications Tested/Suitable for anti-CD38 antibody
Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-CD38 antibody

Western blot analysis using CD38 mouse mouse mAb against CD38-hIgGFc transfected HEK293 cell lysate.
Mouse Anti-CD38 Monoclonal Antibody – Cat# MBS475969

Immunohistochemistry (IHC) of anti-CD38 antibody

Immunohistochemical analysis of paraffin-embedded human lung cancer (A), lymphonodus tissue (B), showing cytomembrane localization using CD38 mouse mAb with DAB staining.
Mouse Anti-CD38 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS475969

Other Notes

Small volumes of anti-CD38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD38 purchase

MBS475969 is an antibody targeting CD38. Also known as Anti-CD38 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD38. It may not necessarily be applicable to this product.

NCBI GI #
1911103
NCBI GeneID
952
NCBI Accession #
BAA18966.1
UniProt Secondary Accession #
O00121; O00122; Q96HY4
UniProt Related Accession #
P28907
NCBI Official Full Name
CD38
NCBI Official Synonym Full Names
CD38 molecule
NCBI Official Symbol
CD38
NCBI Official Synonym Symbols
ADPRC1; ADPRC 1
UniProt Protein Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
UniProt Synonym Protein Names
2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38
Protein Family
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Gene Name
CD38
UniProt Synonym Gene Names
ADPRC 1; cADPr hydrolase 1
NCBI Protein Information
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

NCBI Summary for CD38

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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UniProt Comments for CD38

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell cycle regulation; Cell surface; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.99.20; EC 3.2.2.6; Hydrolase; Lyase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p15.32

Cellular Component: membrane

Molecular Function: NAD+ nucleosidase activity; phosphorus-oxygen lyase activity

Biological Process: B cell receptor signaling pathway; negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of transcription, DNA-dependent; response to drug
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Research Articles on CD38

1. Results may imply that CD38 expression either reflects or participates in pathogenic mechanisms of HIV disease independently of cell cycling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD38 antibody

 Reference Product  PubMed Publications
 CD4 antibody  >1150 publications with CD38 and CD4
 CD27 antibody  >248 publications with CD38 and CD27
 IL6 antibody  >26 publications with CD38 and IL6
 LCK antibody  >8 publications with CD38 and LCK
 BST1 antibody  >3 publications with CD38 and BST1

Pathways associated with anti-CD38 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram

Diseases associated with anti-CD38 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >433 publications with CD38 and Cardiovascular Diseases
 Inflammation Antibodies  >263 publications with CD38 and Inflammation
 Necrosis Antibodies  >200 publications with CD38 and Necrosis
 Liver Diseases Antibodies  >99 publications with CD38 and Liver Diseases
 Nervous System Diseases Antibodies  >97 publications with CD38 and Nervous System Diseases
 Anemia Antibodies  >91 publications with CD38 and Anemia
 Neoplasms, Experimental Antibodies  >77 publications with CD38 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >70 publications with CD38 and Disease Models, Animal
 Carcinoma Antibodies  >63 publications with CD38 and Carcinoma
 Breast Neoplasms Antibodies  >43 publications with CD38 and Breast Neoplasms

Organs/Tissues associated with anti-CD38 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3703 publications with CD38 and Blood
 Bone Marrow Antibodies  >1360 publications with CD38 and Bone Marrow
 Lymph Node Antibodies  >278 publications with CD38 and Lymph Node
 Liver Antibodies  >216 publications with CD38 and Liver
 Lymph Antibodies  >206 publications with CD38 and Lymph
 Spleen Antibodies  >162 publications with CD38 and Spleen
 Muscle Antibodies  >132 publications with CD38 and Muscle
 Brain Antibodies  >118 publications with CD38 and Brain
 Tonsil Antibodies  >112 publications with CD38 and Tonsil
 Pharynx Antibodies  >106 publications with CD38 and Pharynx
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