Mouse Anti-FGFR3 Monoclonal Antibody – Cat# MBS476885

FGFR3 Antibody – Mouse Monoclonal

Name: FGFR3 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS476885
Price: 525 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476885

Entrez Summary: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand… More details

$525 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FGFR3, Monoclonal Antibody

Full Product Name

Anti-FGFR3 Mouse mAb

Product Gene Name

anti-FGFR3 antibody

Product Synonym Names

BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316; EIF4EBP1

Clonality

Monoclonal

Isotype

IgG1

Clone Number

9E12D9

Host

Mouse

Species Reactivity

Human

Form/Format

Ascitic fluid containing 0.03% sodium azide.

Molecular Weight

87.7

OMIM

L36055 mRNA

Immunogen

Purified recombinant fragment of 4EBP1 expressed in E Coli.

Applications Tested/Suitable for anti-FGFR3 antibody

Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

Other Notes

Small volumes of anti-FGFR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGFR3 purchase

MBS476885 is an antibody targeting FGFR3. Also known as Anti-FGFR3 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FGFR3. It may not necessarily be applicable to this product.

NCBI GI #

958832671

NCBI GeneID

1978

NCBI Accession #

JAO86522.1

UniProt Secondary Accession #

Q6IBN3; B2R502; D3DSW8

UniProt Related Accession #

Q13541

NCBI Official Full Name

FGFR3, partial

NCBI Official Synonym Full Names

eukaryotic translation initiation factor 4E binding protein 1

NCBI Official Symbol

EIF4EBP1

NCBI Official Synonym Symbols

BP-1; 4EBP1; 4E-BP1; PHAS-I

UniProt Protein Name

Eukaryotic translation initiation factor 4E-binding protein 1

UniProt Synonym Protein Names

Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

Protein Family

Fibroblast growth factor receptor

UniProt Gene Name

EIF4EBP1

UniProt Synonym Gene Names

4E-BP1; eIF4E-binding protein 1; PHAS-I

NCBI Protein Information

eukaryotic translation initiation factor 4E-binding protein 1

NCBI Summary for FGFR3

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

UniProt Comments for FGFR3

4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 8p11.23

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: eukaryotic initiation factor 4E binding; protein binding; translation repressor activity

Biological Process: G1/S transition of mitotic cell cycle; negative regulation of translational initiation; positive regulation of mitotic cell cycle; TOR signaling pathway

Research Articles on FGFR3

1. Increased expression of miR-125a is associated with invasion and migration in ovarian cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FGFR3 antibody

Reference Product	PubMed Publications
MTOR antibody	>637 publications with FGFR3 and MTOR
EIF4E antibody	>579 publications with FGFR3 and EIF4E
AKT1 antibody	>63 publications with FGFR3 and AKT1
RPTOR antibody	>34 publications with FGFR3 and RPTOR
RICTOR antibody	>18 publications with FGFR3 and RICTOR
EIF4G1 antibody	>14 publications with FGFR3 and EIF4G1
RPS6KB1 antibody	>9 publications with FGFR3 and RPS6KB1
LRRK2 antibody	>6 publications with FGFR3 and LRRK2
MLST8 antibody	>6 publications with FGFR3 and MLST8
MAPKAP1 antibody	>1 publications with FGFR3 and MAPKAP1

Pathways associated with anti-FGFR3 antibody

Products by Pathway	Pathway Diagram
4-hydroxytamoxifen, Dexamethasone, And Retinoic Acids Regulation Of P27 Expression Pathway antibodies	4-hydroxytamoxifen, Dexamethasone, And Retinoic Acids Regulation Of P27 Expression Pathway Diagram
AMP-activated Protein Kinase (AMPK) Signaling Pathway antibodies	AMP-activated Protein Kinase (AMPK) Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies	Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Alpha 6 Beta 4 Signaling Pathway antibodies	Alpha 6 Beta 4 Signaling Pathway Diagram
Angiopoietin Like Protein 8 Regulatory Pathway antibodies	Angiopoietin Like Protein 8 Regulatory Pathway Diagram
BDNF-TrkB Signaling Pathway antibodies	BDNF-TrkB Signaling Pathway Diagram

Diseases associated with anti-FGFR3 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>61 publications with FGFR3 and Breast Neoplasms
Hypertrophy Antibodies	>51 publications with FGFR3 and Hypertrophy
Disease Models, Animal Antibodies	>47 publications with FGFR3 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>42 publications with FGFR3 and Cardiovascular Diseases
Necrosis Antibodies	>31 publications with FGFR3 and Necrosis
Lung Neoplasms Antibodies	>29 publications with FGFR3 and Lung Neoplasms
Neoplasm Metastasis Antibodies	>29 publications with FGFR3 and Neoplasm Metastasis
Neoplasms, Experimental Antibodies	>28 publications with FGFR3 and Neoplasms, Experimental
Kidney Diseases Antibodies	>25 publications with FGFR3 and Kidney Diseases
Cell Transformation, Neoplastic Antibodies	>25 publications with FGFR3 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-FGFR3 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>207 publications with FGFR3 and Muscle
Blood Antibodies	>146 publications with FGFR3 and Blood
Vascular Antibodies	>65 publications with FGFR3 and Vascular
Liver Antibodies	>62 publications with FGFR3 and Liver
Brain Antibodies	>53 publications with FGFR3 and Brain
Heart Antibodies	>47 publications with FGFR3 and Heart
Kidney Antibodies	>46 publications with FGFR3 and Kidney
Lung Antibodies	>45 publications with FGFR3 and Lung
Skin Antibodies	>25 publications with FGFR3 and Skin
Pancreas Antibodies	>25 publications with FGFR3 and Pancreas