• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Alpha Synuclein (Ser129) (SNCA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS502004

MBS502004 is an antibody targeting SNCA. Also known as Anti-Phospho-Ser129 Alpha Synuclein. Reactive in Rat. Host: Rabbit. Affinity purified rabbit polyclonal antibody More details

$495 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Alpha synuclein (ser129) (SNCA), Polyclonal Antibody
Full Product Name
Anti-Phospho-Ser129 Alpha Synuclein
Product Gene Name
anti-SNCA antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Purity/Purification
Affinity Purified (Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.)
Specificity
Specific for the ~15 kDa alpha-synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
Preparation and Storage
Store at -20 degree C; stable for at least one year.
Molecular Weight
15
Chromosome Location
Chromosome: 4; NC_005103.3 (155592411..155690724, complement). Location: 4q24
3D Structure
ModBase 3D Structure for P37377
Antigen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser129 of alpha synuclein.
Immunogen Information
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser129 conjugated to KLH
Immunogen Species
Rat
Reactivity Assumed Based on 100% Sequence Homology
Bovine, canine, human, mouse, and non-human primate
Species Reactivity Note
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, human, mouse, and non-human primate based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Biological Significance
Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005; Masliah et al., 2005).
Applications Tested/Suitable for anti-SNCA antibody
Western Blot (WB)
Application Notes for anti-SNCA antibody
Quality Control: Western blots performed on each lot.
WB: 1:1000

Testing Data of anti-SNCA antibody

Rabbit Anti-SNCA Polyclonal Antibody – Cat# MBS502004

Product References and Citations for anti-SNCA antibody

• Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000) Constitutive phosphorylation of the Parkinson's disease associated alphasynuclein. J Biol Chem Jan 7;275(1): 390-7.
• Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C (2002) Misfolded proteinase k resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha synucleinopathies. J Clin Invest Nov; 110(10):1403-5.
• Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson TM, Iwatsubo T, Ross CA (2005) Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y Cells. J Neurosci June 8; 25(23):5544-5552.
• Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Suebert P, Lee M, Goldstein J, Chilcote T, Games D, Schenk D (2005) Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron Jun 16;46(6):857-868.

Other Notes

Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.

NCBI GI #
9507125
NCBI GeneID
29219
NCBI Accession #
NP_062042.1
UniProt Primary Accession #
P37377
UniProt Secondary Accession #
P37378; Q53YM9
UniProt Related Accession #
P37377
GenBank Nucleotide #
NM_019169.2
NCBI Official Full Name
alpha-synuclein
NCBI Official Synonym Full Names
synuclein, alpha (non A4 component of amyloid precursor)
NCBI Official Symbol
Snca
UniProt Protein Name
Alpha-synuclein
Protein Family
Alpha-synuclein
UniProt Gene Name
Snca
UniProt Entry Name
SYUA_RAT
NCBI Protein Information
alpha-synuclein

NCBI Summary for SNCA

may play a role in regulation of synaptic vesicle biogenesis and organization; may be involved in neurotransmission [RGD, Feb 2006]

UniProt Comments for SNCA

Function: May be involved in the regulation of dopamine release and transport.

Subunit structure: Interacts with UCHL1. Ref.7

Subcellular location: Cytoplasm

By similarity.

Tissue specificity: Found only in brain (hippocampus, brainstem and cortex). Specifically expressed in neuronal cell bodies and synapses.

Post-translational modification: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress

By similarity.Ubiquitinated. The predominant conjugate is the diubiquitinated form. Ref.7Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure

By similarity.

Sequence similarities: Belongs to the synuclein family.
Show more

Research Articles on SNCA

1. Our data show that changes in the S129 residue of alpha-synuclein influence the rate of pathology and neurodegeneration

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SNCA antibody

 Reference Product  PubMed Publications
 Park2 antibody  >875 publications with SNCA and Park2
 Lrrk2 antibody  >123 publications with SNCA and Lrrk2
 Mapt antibody  >72 publications with SNCA and Mapt
 Park7 antibody  >51 publications with SNCA and Park7
 Sncaip antibody  >31 publications with SNCA and Sncaip
 Slc6a3 antibody  >12 publications with SNCA and Slc6a3
 Stub1 antibody  >1 publications with SNCA and Stub1

Pathways associated with anti-SNCA antibody

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram

Diseases associated with anti-SNCA antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1090 publications with SNCA and Nervous System Diseases
 Brain Diseases Antibodies  >1068 publications with SNCA and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1056 publications with SNCA and Neurodegenerative Diseases
 Movement Disorders Antibodies  >934 publications with SNCA and Movement Disorders
 Parkinsonian Disorders Antibodies  >867 publications with SNCA and Parkinsonian Disorders
 Parkinson Disease Antibodies  >815 publications with SNCA and Parkinson Disease
 Lewy Body Disease Antibodies  >274 publications with SNCA and Lewy Body Disease
 Nerve Degeneration Antibodies  >163 publications with SNCA and Nerve Degeneration
 Disease Models, Animal Antibodies  >133 publications with SNCA and Disease Models, Animal
 Neoplasms Antibodies  >58 publications with SNCA and Neoplasms

Organs/Tissues associated with anti-SNCA antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >744 publications with SNCA and Brain
 Eye Antibodies  >10 publications with SNCA and Eye
 Heart Antibodies  >9 publications with SNCA and Heart
 Liver Antibodies  >7 publications with SNCA and Liver
 Dorsal Root Ganglion Antibodies  >5 publications with SNCA and Dorsal Root Ganglion
 Prostate Antibodies  >1 publications with SNCA and Prostate
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000