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STAT6 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515141

Full-length recombinant human STAT6 was expressed in Sf9 insect cells using an N-terminal GST tag.Scientific Background: The STAT6 protein is a member of the STAT family of transcription factors that are activated by cytokines and phosphorylated by the… More details

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Product Overview

Online Datasheet in PDF
Product Name
STAT6, Recombinant Protein
Full Product Name
STAT6 recombinant protein
Product Gene Name
STAT6 recombinant protein
Product Synonym Gene Name
STAT6B; STAT6C; D12S1644; IL-4-STAT
Product Synonym Names
STAT6B; STAT6C; D12S1644; IL-4-STAT
Host
Sf9 insect cells
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity/Purification
>90%
Concentration
0.2 ug/ul (lot specific)
Preparation and Storage
Store product at –70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~138 kDa
Chromosome Location
Chromosome: 12; NC_000012.11 (57489187..57505196, complement). Location: 12q13
OMIM
601512
3D Structure
ModBase 3D Structure for P42226
Species
Human
Tag Information
GST tag
Source Note
Full-length recombinant human STAT6 was expressed in Sf9 insect cells.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for STAT6 recombinant protein

Transcription Proteins; Signaling Proteins - Transcription Proteins
Applications Tested/Suitable for STAT6 recombinant protein
Kinase Assay, Western Blot (WB)

SDS-PAGE of STAT6 recombinant protein

The purity of STAT6 protein was determined to be >90% by densitometry.
Approx. MW 138 kDa.
STAT6 Recombinant Protein – Cat# MBS515141

Product References and Citations for STAT6 recombinant protein

1. Weidinger, S. et al: Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. J. Med. Genet. 41: 658-663, 2004.
2.Wang, W. et al: The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells. J. Immun. 172: 97-103, 2004.

Other Notes

Small volumes of STAT6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STAT6 purchase

MBS515141 is a recombinant protein targeting STAT6. Host: Sf9 insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT6. It may not necessarily be applicable to this product.

NCBI GI #
49904291
NCBI GeneID
6778
NCBI Accession #
BC075852
UniProt Primary Accession #
P42226
UniProt Secondary Accession #
Q5FBW5; Q71UP4; A8K316; B7ZA27; F5GXI9
UniProt Related Accession #
P42226
NCBI Official Full Name
Homo sapiens signal transducer and activator of transcription 6, interleukin-4 induced, mRNA
NCBI Official Synonym Full Names
signal transducer and activator of transcription 6, interleukin-4 induced
NCBI Official Symbol
STAT6
NCBI Official Synonym Symbols
STAT6B; STAT6C; D12S1644; IL-4-STAT
UniProt Protein Name
Signal transducer and activator of transcription 6
UniProt Synonym Protein Names
IL-4 Stat
Protein Family
Signal transducer and activator of transcription
UniProt Gene Name
STAT6
UniProt Entry Name
STAT6_HUMAN
NCBI Protein Information
signal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT

NCBI Summary for STAT6

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for STAT6

Function: Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Ref.9

Subunit structure: Forms a homodimer or a heterodimer with a related family member

By similarity. Interacts with NCOA1 via its C-terminal LXXLL motif. Ref.8

Subcellular location: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation.

Post-translational modification: Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3

By similarity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling. Ref.9

Sequence similarities: Belongs to the transcription factor STAT family.Contains 1 SH2 domain.
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Research Articles on STAT6

1. The interaction term [IL13 (rs20541) x STAT6 (rs1059513)] was statistically significant in both studies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with STAT6 recombinant protein

 Reference Product  PubMed Publications
 JAK1 recombinant protein  >121 publications with STAT6 and JAK1
 JAK3 recombinant protein  >100 publications with STAT6 and JAK3
 JAK2 recombinant protein  >81 publications with STAT6 and JAK2
 CCL11 recombinant protein  >56 publications with STAT6 and CCL11
 SOCS1 recombinant protein  >47 publications with STAT6 and SOCS1
 IL4R recombinant protein  >22 publications with STAT6 and IL4R
 CCL17 recombinant protein  >20 publications with STAT6 and CCL17
 NCOA1 recombinant protein  >10 publications with STAT6 and NCOA1
 CREBBP recombinant protein  >5 publications with STAT6 and CREBBP

Pathways associated with STAT6 recombinant protein

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-4 Signaling Pathway antibodies  IL-4 Signaling Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram

Diseases associated with STAT6 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >383 publications with STAT6 and Inflammation
 Lung Diseases Antibodies  >250 publications with STAT6 and Lung Diseases
 Neoplasms Antibodies  >208 publications with STAT6 and Neoplasms
 Necrosis Antibodies  >142 publications with STAT6 and Necrosis
 Nervous System Diseases Antibodies  >60 publications with STAT6 and Nervous System Diseases
 Dermatitis, Atopic Antibodies  >55 publications with STAT6 and Dermatitis, Atopic
 Cardiovascular Diseases Antibodies  >46 publications with STAT6 and Cardiovascular Diseases
 Liver Diseases Antibodies  >44 publications with STAT6 and Liver Diseases
 Hyperplasia Antibodies  >41 publications with STAT6 and Hyperplasia
 Neoplasms, Experimental Antibodies  >39 publications with STAT6 and Neoplasms, Experimental

Organs/Tissues associated with STAT6 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >996 publications with STAT6 and Blood
 Lung Antibodies  >276 publications with STAT6 and Lung
 Bone Antibodies  >115 publications with STAT6 and Bone
 Bone Marrow Antibodies  >98 publications with STAT6 and Bone Marrow
 Spleen Antibodies  >97 publications with STAT6 and Spleen
 Intestine Antibodies  >96 publications with STAT6 and Intestine
 Muscle Antibodies  >91 publications with STAT6 and Muscle
 Liver Antibodies  >89 publications with STAT6 and Liver
 Skin Antibodies  >80 publications with STAT6 and Skin
 Lymph Node Antibodies  >68 publications with STAT6 and Lymph Node
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