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SHROOM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243051

MBS243051 is an antibody targeting SHROOM2. Also known as Rabbit Polyclonal to Human SHROOM2. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SHROOM2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human SHROOM2
Product Gene Name
anti-SHROOM2 antibody
Product Synonym Names
Anti-SHROOM2 Antibody IHC-plus; SHROOM2; Apical-like protein; HSAPXL; Protein APXL; Protein Shroom2; APX homolog of Xenopus; APXL; Shroom family member 2; Human SHROOM2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human APXL.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
176,410 Da
OMIM
300103
3D Structure
ModBase 3D Structure for Q13796
Target Species
Human
Immunogen Description
Synthetic peptide containing a sequence corresponding to a region within amino acids 1554 and 1616 of Human APXL.
Immunogen Type
Synthetic peptide
Immunogen
SHROOM2 antibody was raised against synthetic peptide containing a sequence corresponding to a region within amino acids 1554 and 1616 of Human APXL.
Applications Tested/Suitable for anti-SHROOM2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-SHROOM2 antibody
IHC-P (10 ug/ml), WB (1:500 - 1:3000)

Immunohistochemistry (IHC) of anti-SHROOM2 antibody

Anti-SHROOM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-SHROOM2 Polyclonal Antibody – Cat# MBS243051

Immunohistochemistry (IHC) of anti-SHROOM2 antibody

Anti-SHROOM2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-SHROOM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243051

Western Blot (WB) of anti-SHROOM2 antibody

Sample (30 ug of whole cell lysate). A: Hep G2. 5% SDS PAGE. SHROOM2 antibody diluted at 1:500.
Rabbit Anti-SHROOM2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243051

Other Notes

Small volumes of anti-SHROOM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SHROOM2. It may not necessarily be applicable to this product.

NCBI GI #
4502175
NCBI GeneID
357
NCBI Accession #
NP_001640.1
UniProt Primary Accession #
Q13796
UniProt Secondary Accession #
B9EIQ7
UniProt Related Accession #
Q13796
GenBank Nucleotide #
NM_001649.2
NCBI Official Full Name
protein Shroom2
NCBI Official Synonym Full Names
shroom family member 2
NCBI Official Symbol
SHROOM2
NCBI Official Synonym Symbols
APXL; HSAPXL
UniProt Protein Name
Protein Shroom2
UniProt Synonym Protein Names
Apical-like protein; Protein APXL
Protein Family
Protein
UniProt Gene Name
SHROOM2
UniProt Synonym Gene Names
APXL
UniProt Entry Name
SHRM2_HUMAN
NCBI Protein Information
protein Shroom2; apical-like protein; APX homolog of Xenopus

NCBI Summary for SHROOM2

The protein encoded by this gene shares significant similarities with the apical protein from Xenopus laevis which is implicated in amiloride-sensitive sodium channel activity. This gene is a strong candidate gene for ocular albinism type 1 syndrome. [provided by RefSeq, Jul 2008]

UniProt Comments for SHROOM2

APXL: May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution. Belongs to the shroom family.

Protein type: Channel, sodium

Chromosomal Location of Human Ortholog: Xp22.3

Cellular Component: filamentous actin; microtubule; cortical actin cytoskeleton; tight junction; cell-cell adherens junction; cytoskeleton; cell soma; apical plasma membrane; plasma membrane

Molecular Function: actin filament binding; amiloride-sensitive sodium channel activity; protein domain specific binding; protein binding; beta-catenin binding; actin binding

Biological Process: eye pigment granule organization and biogenesis; actin filament bundle formation; cell migration; camera-type eye development; cell morphogenesis; negative regulation of actin filament depolymerization; ear development; cellular pigment accumulation; apical protein localization; camera-type eye morphogenesis; melanosome organization and biogenesis; establishment of melanosome localization; lens morphogenesis in camera-type eye; brain development; intercellular junction maintenance
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Research Articles on SHROOM2

1. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 x 10(-10)).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SHROOM2 antibody

 Reference Product  PubMed Publications
 GPR143 antibody  >2 publications with SHROOM2 and GPR143
 TBL1X antibody  >1 publications with SHROOM2 and TBL1X

Pathways associated with anti-SHROOM2 antibody

 Products by Pathway  Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram

Diseases associated with anti-SHROOM2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with SHROOM2 and Nervous System Diseases
 Inflammation Antibodies  >1 publications with SHROOM2 and Inflammation

Organs/Tissues associated with anti-SHROOM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >3 publications with SHROOM2 and Eye
 Brain Antibodies  >3 publications with SHROOM2 and Brain
 Placenta Antibodies  >2 publications with SHROOM2 and Placenta
 Embryonic Tissue Antibodies  >2 publications with SHROOM2 and Embryonic Tissue
 Muscle Antibodies  >1 publications with SHROOM2 and Muscle
 Bone Antibodies  >1 publications with SHROOM2 and Bone
 Kidney Antibodies  >1 publications with SHROOM2 and Kidney
 Lung Antibodies  >1 publications with SHROOM2 and Lung
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