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Aurora C (AURKC) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515455

Description: Recombinant full-length human AURORA C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome… More details

$445 / 0.01 mg +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Aurora C (AURKC), Recombinant Protein
Full Product Name
Aurora C, Active
Product Gene Name
AURKC recombinant protein
Product Synonym Gene Name
AIE2; AIK3; AurC; STK13; aurora-C
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~61 kDa
Sequence Positions
Full Length
OMIM
AF054621 mRNA
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for AURKC recombinant protein

Enzymes; Active Kinases
Applications Tested/Suitable for AURKC recombinant protein
Kinase Assay, Western Blot (WB)

Testing Data of AURKC recombinant protein

AURKC Recombinant Protein – Cat# MBS515455

Testing Data #2 of AURKC recombinant protein

AURKC Recombinant Protein, Testing Data #2 – Cat# MBS515455

Product References and Citations for AURKC recombinant protein

1. Steven, L. et al: Targeting Aurora-2 Kinase in Cancer. Molecular Cancer Therapeutics. 2003;2: 589-595 2. Shingo, T. et al: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes to Cells. 2004; 9: 383-397

Other Notes

Small volumes of AURKC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AURKC purchase

MBS515455 is a recombinant protein targeting AURKC. Also known as Aurora C, Active. Host: Sf9 insect cells using baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for AURKC. It may not necessarily be applicable to this product.

NCBI GI #
62865642
NCBI GeneID
6795
NCBI Accession #
NM_003160.2
UniProt Secondary Accession #
O60681; O75442; Q6AZY8; Q6DLZ0; Q9UPK5
UniProt Related Accession #
Q9UQB9
GenBank Nucleotide #
NM_003160
NCBI Official Full Name
Homo sapiens aurora kinase C (AURKC), transcript variant 3, mRNA
NCBI Official Synonym Full Names
aurora kinase C
NCBI Official Symbol
AURKC
NCBI Official Synonym Symbols
AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
UniProt Protein Name
Aurora kinase C
UniProt Synonym Protein Names
Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C
Protein Family
Aurora kinase
UniProt Gene Name
AURKC
UniProt Synonym Gene Names
AIE2; AIK3; AIRK3; ARK3; STK13; ARK-3; Aurora-related kinase 3
NCBI Protein Information
aurora kinase C

NCBI Summary for AURKC

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
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UniProt Comments for AURKC

AurC: a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described.

Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: condensed chromosome; condensed nuclear chromosome, pericentric region; midbody; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function: histone serine kinase activity; protein binding; protein kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: attachment of spindle microtubules to kinetochore; histone modification; positive regulation of cytokinesis; protein amino acid phosphorylation; spindle midzone assembly involved in mitosis

Disease: Spermatogenic Failure 5
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Research Articles on AURKC

1. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AURKC recombinant protein

 Reference Product  PubMed Publications
 AURKB recombinant protein  >8 publications with AURKC and AURKB
 CEBPD recombinant protein  >1 publications with AURKC and CEBPD

Pathways associated with AURKC recombinant protein

 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Aurora C Signaling Pathway antibodies  Aurora C Signaling Pathway Diagram
 Signaling By Aurora Kinases Pathway antibodies  Signaling By Aurora Kinases Pathway Diagram

Diseases associated with AURKC recombinant protein

 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >7 publications with AURKC and Infertility, Male
 Infertility, Female Antibodies  >3 publications with AURKC and Infertility, Female
 Neoplasms Antibodies  >3 publications with AURKC and Neoplasms
 Abnormalities, Multiple Antibodies  >2 publications with AURKC and Abnormalities, Multiple
 Necrosis Antibodies  >2 publications with AURKC and Necrosis
 Inflammation Antibodies  >1 publications with AURKC and Inflammation
 Embryo Loss Antibodies  >1 publications with AURKC and Embryo Loss

Organs/Tissues associated with AURKC recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >1 publications with AURKC and Testis
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