JNK1 Recombinant Protein

JNK1: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, pro-inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. Substrates include a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2, thus regulating AP-1 transcriptional activity. In T- cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Activity increased in obesity. Inhibition or mouse knockout increases insulin sensitivity. Part of NFB pathway involved in inflammation and cancer, and signals downstream of Ras, though possibly as an apoptotic negative regulator of growth. Four alternatively-spliced isoforms have been described.

Protein type: CMGC group; EC 2.7.11.24; JNK subfamily; Kinase, protein; MAPK family; MAPK/JNK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 14|14 B

Cellular Component: axon; cytoplasm; cytosol; dendrite cytoplasm; mitochondrion; neuron projection; nucleus; perikaryon; podosome; vesicle

Molecular Function: enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; kinesin binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: cellular response to amino acid starvation; dendrite morphogenesis; determination of dorsal identity; inflammatory response; JNK cascade; JUN phosphorylation; negative regulation of apoptosis; negative regulation of protein binding; neurite development; neuron migration; ossification; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell migration; positive regulation of cyclase activity; positive regulation of DNA replication; positive regulation of microtubule polymerization; positive regulation of neuroblast proliferation; positive regulation of neuron apoptosis; positive regulation of protein metabolic process; protein amino acid phosphorylation; regulation of centrosome cycle; regulation of circadian rhythm; regulation of gene expression; regulation of neuron differentiation; regulation of protein localization; regulation of transcription, DNA-dependent; response to cadmium ion; response to heat; response to hydrogen peroxide; response to mechanical stimulus; response to osmotic stress; response to UV; signal transduction; stress-activated MAPK cascade