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TPM3-TRKA Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515560

Description: Recombinant human fusion protein TPM3 (1-258)-TRKA (399-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is… More details

$480 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TPM3-TRKA, Recombinant Protein
Full Product Name
TPM3-TRKA Mutant, Active
Product Gene Name
TPM3-TRKA recombinant protein
Product Synonym Gene Name
CAPM1; CFTD; hscp30; NEM1; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3; OK/SW-cl.5
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity/Purification
>70%
Concentration
0.05ug/ul (lot specific)
Preparation and Storage
Ships on dry ice. Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~105 kDa
OMIM
X04201 mRNA
3D Structure
ModBase 3D Structure for P06753
Specific Activity
13 nmol/min/mg
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for TPM3-TRKA recombinant protein

Enzymes; Active Kinase Mutants

Testing Data of TPM3-TRKA recombinant protein

The purity of TPM3-TRKA was determined to be >70% by densitometry, approx. MW 105kDa.
TPM3-TRKA Recombinant Protein – Cat# MBS515560

Testing Data #2 of TPM3-TRKA recombinant protein

The specific activity of TPM3-TRKA was determined to be 13 nmol /min/mg as per activity assay protocol.
TPM3-TRKA Recombinant Protein, Testing Data #2 – Cat# MBS515560

Product References and Citations for TPM3-TRKA recombinant protein

1. Smeyne, R. J. et.al: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368: 246-249, 1994. 2. Marta G. B. et.al: A Sequence Analysis of the Genomic Regions Involved in the Rearrangements between TPM3 and NTRK1 Genes Producing TRK Oncogenes in Papillary Thyroid Carcinomas. Genomics, Volume 28, Issue 1, 1 July 1995, Pages 15 -24

Other Notes

Small volumes of TPM3-TRKA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TPM3-TRKA purchase

MBS515560 is a recombinant protein targeting TPM3-TRKA. Also known as TPM3-TRKA Mutant, Active.

Additional Details

NCBI/Uniprot data below describe general gene information for TPM3-TRKA. It may not necessarily be applicable to this product.

NCBI GI #
499137514
NCBI GeneID
7170
NCBI Accession #
NM_152263.3
UniProt Primary Accession #
P06753
UniProt Secondary Accession #
P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8; D3DV71
UniProt Related Accession #
P06753
GenBank Nucleotide #
NM_152263
NCBI Official Full Name
Homo sapiens tropomyosin 3 (TPM3), transcript variant Tpm3.12, mRNA
NCBI Official Synonym Full Names
tropomyosin 3
NCBI Official Symbol
TPM3
NCBI Official Synonym Symbols
TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; TM30nm; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5
UniProt Protein Name
Tropomyosin alpha-3 chain
UniProt Synonym Protein Names
Gamma-tropomyosin; Tropomyosin-3; Tropomyosin-5; hTM5
UniProt Gene Name
TPM3
UniProt Synonym Gene Names
hTM5
NCBI Protein Information
tropomyosin alpha-3 chain

NCBI Summary for TPM3-TRKA

This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
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UniProt Comments for TPM3-TRKA

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
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Research Articles on TPM3-TRKA

1. Dominant mutations in TPM3, encoding alpha-tropomyosinslow, cause a congenital myopathy characterized by generalized muscle weakness. Here, we used a multidisciplinary approach to investigate the mechanism of muscle dysfunction in 12 TPM3-myopathy patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TPM3-TRKA recombinant protein

 Reference Product  PubMed Publications
 TPM1 recombinant protein  >250 publications with TPM3-TRKA and TPM1
 TPM2 recombinant protein  >111 publications with TPM3-TRKA and TPM2
 TNNT1 recombinant protein  >17 publications with TPM3-TRKA and TNNT1
 TNNT3 recombinant protein  >10 publications with TPM3-TRKA and TNNT3
 ACTC1 recombinant protein  >8 publications with TPM3-TRKA and ACTC1
 ACTA2 recombinant protein  >8 publications with TPM3-TRKA and ACTA2
 MYH3 recombinant protein  >5 publications with TPM3-TRKA and MYH3
 ACTN2 recombinant protein  >1 publications with TPM3-TRKA and ACTN2
 ACTG2 recombinant protein  >1 publications with TPM3-TRKA and ACTG2

Pathways associated with TPM3-TRKA recombinant protein

 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram

Diseases associated with TPM3-TRKA recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >555 publications with TPM3-TRKA and Cardiovascular Diseases
 Heart Diseases Antibodies  >473 publications with TPM3-TRKA and Heart Diseases
 Carcinoma Antibodies  >181 publications with TPM3-TRKA and Carcinoma
 Hypertrophy Antibodies  >150 publications with TPM3-TRKA and Hypertrophy
 Inflammation Antibodies  >109 publications with TPM3-TRKA and Inflammation
 Cell Transformation, Neoplastic Antibodies  >101 publications with TPM3-TRKA and Cell Transformation, Neoplastic
 MYOPATHY, CONGENITAL, WITH FIBER-TYPE DISPROPORTION Antibodies  >97 publications with TPM3-TRKA and MYOPATHY, CONGENITAL, WITH FIBER-TYPE DISPROPORTION
 Lung Diseases Antibodies  >89 publications with TPM3-TRKA and Lung Diseases
 Adenocarcinoma Antibodies  >78 publications with TPM3-TRKA and Adenocarcinoma
 Fibrosis Antibodies  >53 publications with TPM3-TRKA and Fibrosis

Organs/Tissues associated with TPM3-TRKA recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3895 publications with TPM3-TRKA and Muscle
 Heart Antibodies  >989 publications with TPM3-TRKA and Heart
 Brain Antibodies  >854 publications with TPM3-TRKA and Brain
 Blood Antibodies  >644 publications with TPM3-TRKA and Blood
 Nerve Antibodies  >449 publications with TPM3-TRKA and Nerve
 Embryonic Tissue Antibodies  >314 publications with TPM3-TRKA and Embryonic Tissue
 Vascular Antibodies  >276 publications with TPM3-TRKA and Vascular
 Lung Antibodies  >196 publications with TPM3-TRKA and Lung
 Skin Antibodies  >153 publications with TPM3-TRKA and Skin
 Liver Antibodies  >126 publications with TPM3-TRKA and Liver
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