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PIP5K1C Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515572

Description: Recombinant full-length human PIP5K1C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: PIP5K1C or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate… More details

$505 / 0.01 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PIP5K1C, Active Protein
Full Product Name
PIP5K1C, Active
Product Gene Name
PIP5K1C active protein
Product Synonym Gene Name
KIAA0589; LCCS3; PIP5K-GAMMA; PIP5Kgamma; PIPKIg_v4
Product Synonym Names
KIAA0589; LCCS3; PlP5K-GAMMA; PlP5Kgamma; PlPKlg_v4
Host
Sf9 cells
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM, DTT, 0.1mM PMSF, and 25% glycerol.
Purity/Purification
>80%
Concentration
0.1 mg/ml (lot specific)
Preparation and Storage
Ships on dry ice. Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
OMIM
FJ965536 mRNA
3D Structure
ModBase 3D Structure for O60331
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Host Note
Recombinant full length human protein expressed in Sf9 cells.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for PIP5K1C active protein

Enzymes; Active Lipid Kinases

Specific Activity of PIP5K1C active protein

The specific activity of PIP5K1C was determined to be 6,927 nmol/min/mg as per activity assay protocol.
PIP5K1C Active Protein – Cat# MBS515572

Purity of PIP5K1C active protein

The purity of PIP5K1C was detrermined to be >70% by densitometry approx. MW 120 kDa.
PIP5K1C Active Protein, Purity – Cat# MBS515572

Product References and Citations for PIP5K1C active protein

1. Schramp M. et al: PIPKIgamma regulates beta-catenin transcriptional activity downstream of growth factor receptor signaling. Cancer Res. 2011 Feb 15;71 (4):1282-91. 2. Xu W, Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity. 2010 Sep 24;33 (3):340-50.

Other Notes

Small volumes of PIP5K1C active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PIP5K1C purchase

MBS515572 is an active protein targeting PIP5K1C. Also known as PIP5K1C, Active. Host: Sf9 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for PIP5K1C. It may not necessarily be applicable to this product.

NCBI GI #
307691177
NCBI GeneID
23396
NCBI Accession #
NM_012398.2
UniProt Primary Accession #
O60331
UniProt Secondary Accession #
Q7LE07; B7Z9E7; C6GIJ7; C6GIJ8
UniProt Related Accession #
O60331
GenBank Nucleotide #
NM_012398
NCBI Official Full Name
Homo sapiens phosphatidylinositol-4-phosphate 5-kinase type 1 gamma (PIP5K1C), transcript variant 2, mRNA
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
NCBI Official Symbol
PIP5K1C
NCBI Official Synonym Symbols
LCCS3; PIP5Kgamma; PIP5K-GAMMA; PIP5K1-gamma
UniProt Protein Name
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
UniProt Synonym Protein Names
Phosphatidylinositol 4-phosphate 5-kinase type I gamma; PIP5KIgamma
Protein Family
Phosphatidylinositol 4-phosphate 5-kinase
UniProt Gene Name
PIP5K1C
UniProt Synonym Gene Names
KIAA0589; PIP5K1-gamma; PtdIns(4)P-5-kinase 1 gamma; PIP5KIgamma
NCBI Protein Information
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

NCBI Summary for PIP5K1C

This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]
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UniProt Comments for PIP5K1C

PIP5K1C: a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.

Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytosol; focal adhesion; nucleoplasm; uropod

Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; cell-cell adhesion; neutrophil chemotaxis; phagocytosis; phosphatidylinositol biosynthetic process; regulation of phosphoinositide 3-kinase cascade; synaptic vesicle endocytosis; synaptic vesicle exocytosis

Disease: Lethal Congenital Contracture Syndrome 3
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Research Articles on PIP5K1C

1. FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PIP5K1C active protein

 Reference Product  PubMed Publications
 PLCB4 active protein  >1 publications with PIP5K1C and PLCB4
 PLCB1 active protein  >1 publications with PIP5K1C and PLCB1

Pathways associated with PIP5K1C active protein

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Clathrin-mediated Endocytosis Pathway antibodies  Clathrin-mediated Endocytosis Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram

Diseases associated with PIP5K1C active protein

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1 publications with PIP5K1C and Adenocarcinoma
 Lung Neoplasms Antibodies  >1 publications with PIP5K1C and Lung Neoplasms
 Vascular Diseases Antibodies  >1 publications with PIP5K1C and Vascular Diseases
 Cardiovascular Diseases Antibodies  >1 publications with PIP5K1C and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with PIP5K1C and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >1 publications with PIP5K1C and Neoplasm Metastasis
 Inflammation Antibodies  >1 publications with PIP5K1C and Inflammation
 Liver Neoplasms Antibodies  >1 publications with PIP5K1C and Liver Neoplasms
 Lethal Congenital Contractural Syndrome 3 Antibodies  >1 publications with PIP5K1C and Lethal Congenital Contractural Syndrome 3

Organs/Tissues associated with PIP5K1C active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with PIP5K1C and Blood
 Vascular Antibodies  >2 publications with PIP5K1C and Vascular
 Ganglia Antibodies  >1 publications with PIP5K1C and Ganglia
 Bladder Antibodies  >1 publications with PIP5K1C and Bladder
 Lung Antibodies  >1 publications with PIP5K1C and Lung
 Kidney Antibodies  >1 publications with PIP5K1C and Kidney
 Testis Antibodies  >1 publications with PIP5K1C and Testis
 Brain Antibodies  >1 publications with PIP5K1C and Brain
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