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PIP4K2B Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515620

Description: Recombinant full-length human PIP4K2B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase, type II, beta) catalyzes the phosphorylation of… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PIP4K2B, Recombinant Protein
Full Product Name
PIP4K2B, Active
Product Gene Name
PIP4K2B recombinant protein
Product Synonym Gene Name
PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
73 kDa
Sequence Positions
Full length
OMIM
U85245 mRNA
3D Structure
ModBase 3D Structure for P78356
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for PIP4K2B recombinant protein

Enzymes; Active Lipid Kinases
Applications Tested/Suitable for PIP4K2B recombinant protein
Kinase Assay

Testing Data of PIP4K2B recombinant protein

PIP4K2B Recombinant Protein – Cat# MBS515620

Testing Data #2 of PIP4K2B recombinant protein

PIP4K2B Recombinant Protein, Testing Data #2 – Cat# MBS515620

Product References and Citations for PIP4K2B recombinant protein

1. Castellino. et.al: A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J. Biol. Chem. 272: 5861-5870, 1997. 2. Lamia, K. A. et.al: Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta -/- mice. Molec. Cell. Biol. 24: 5080-5087, 2004.

Other Notes

Small volumes of PIP4K2B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PIP4K2B purchase

MBS515620 is a recombinant protein targeting PIP4K2B. Also known as PIP4K2B, Active. Host: Sf9 insect cells using baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for PIP4K2B. It may not necessarily be applicable to this product.

NCBI GI #
117938278
NCBI GeneID
8396
NCBI Accession #
NM_003559.4
UniProt Primary Accession #
P78356
UniProt Secondary Accession #
Q5U0E8; Q8TBP2
UniProt Related Accession #
P78356
GenBank Nucleotide #
NM_003559
NCBI Official Full Name
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase type 2 beta (PIP4K2B), mRNA
NCBI Official Synonym Full Names
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
NCBI Official Symbol
PIP4K2B
NCBI Official Synonym Symbols
PI5P4KB; PIP5K2B; PIP5KIIB; PIP5P4KB; PIP5KIIbeta
UniProt Protein Name
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
UniProt Synonym Protein Names
1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PtdIns(5)P-4-kinase isoform 2-beta
Protein Family
Phosphatidylinositol 5-phosphate 4-kinase
UniProt Gene Name
PIP4K2B
UniProt Synonym Gene Names
PIP5K2B; PI(5)P 4-kinase type II beta; PIP4KII-beta
NCBI Protein Information
phosphatidylinositol 5-phosphate 4-kinase type-2 beta

NCBI Summary for PIP4K2B

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
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UniProt Comments for PIP4K2B

PIP4K2B: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: autophagic vacuole; cytosol; nucleoplasm

Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; protein binding; protein homodimerization activity; receptor signaling protein activity

Biological Process: cell surface receptor linked signal transduction; phosphatidylinositol biosynthetic process; phospholipid metabolic process; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade
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Research Articles on PIP4K2B

1. Suppression of PIP4K expression selectively prevents tumor cell growth in vitro and prevents tumor development in mice that have lost the tumor suppressor p53. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PIP4K2B recombinant protein

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PI Metabolism Pathway antibodies  PI Metabolism Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
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