CHP cDNA Clone – Calcium Binding Protein P22 (Human)

This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]

CHP: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate- phosphorylations in a calcium-dependent manner. Belongs to the calcineurin regulatory subunit family. CHP subfamily.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 15q13.3

Cellular Component: cytoplasm; endoplasmic reticulum; focal adhesion; Golgi membrane; microtubule cytoskeleton; nucleus; plasma membrane; transport vesicle

Molecular Function: calcium ion binding; calcium-dependent protein binding; kinase binding; microtubule binding; potassium channel regulator activity; protein binding; transporter activity

Biological Process: cytoplasmic microtubule organization and biogenesis; hyaluronan catabolic process; inhibition of NF-kappaB transcription factor; membrane docking; microtubule bundle formation; negative regulation of protein amino acid autophosphorylation; negative regulation of protein amino acid phosphorylation; negative regulation of protein import into nucleus; negative regulation of protein kinase activity; negative regulation of protein ubiquitination; positive regulation of protein amino acid glycosylation; positive regulation of protein transport; positive regulation of sodium:hydrogen antiporter activity; potassium ion transport; protein export from nucleus; protein stabilization; regulation of intracellular pH; small GTPase mediated signal transduction