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PDE7B Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515638

Description: Full-length recombinant human PDE7B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: PDE7B is a cAMP-specific phosphodiesterase and a member of the cyclic nucleotide phosphodiesterase family that… More details

$505 / 0.01 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PDE7B, Active Protein
Full Product Name
PDE7B, Active
Product Gene Name
PDE7B active protein
Product Synonym Gene Name
MGC88256; bA472E5.1
Host
Sf9 cells
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity/Purification
>75%
Concentration
0.1 ug/ul (lot specific)
Preparation and Storage
Shipping: Dry Ice
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~73 kDa
OMIM
AB038040 mRNA
3D Structure
ModBase 3D Structure for Q9NP56
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Specific Activity
25 nmol/min/mg
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for PDE7B active protein

Enzymes; Active Phosphodiesterases

Specific Activity of PDE7B active protein

PDE7B Active Protein – Cat# MBS515638

Purity of PDE7B active protein

PDE7B Active Protein, Purity – Cat# MBS515638

Product References and Citations for PDE7B active protein

1. Hetman, J. M. et.al: Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc. Nat. Acad. Sci. 97: 472-476, 2000. 2. Ikeda, M. et al: Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biol Psychiatry. 2010 Feb 1;67 (3):263-9.

Other Notes

Small volumes of PDE7B active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE7B purchase

MBS515638 is an active protein targeting PDE7B. Also known as PDE7B, Active. Host: Sf9 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE7B. It may not necessarily be applicable to this product.

NCBI GI #
57242789
NCBI GeneID
27115
NCBI Accession #
NM_018945.3
UniProt Primary Accession #
Q9NP56
UniProt Secondary Accession #
Q5W154
UniProt Related Accession #
Q9NP56
GenBank Nucleotide #
NM_018945
NCBI Official Full Name
Homo sapiens phosphodiesterase 7B (PDE7B), mRNA
NCBI Official Synonym Full Names
phosphodiesterase 7B
NCBI Official Symbol
PDE7B
NCBI Official Synonym Symbols
bA472E5.1
UniProt Protein Name
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Protein Family
cAMP-specific 3',5'-cyclic phosphodiesterase
UniProt Gene Name
PDE7B
NCBI Protein Information
cAMP-specific 3',5'-cyclic phosphodiesterase 7B

NCBI Summary for PDE7B

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]
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UniProt Comments for PDE7B

PDE7B: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.

Protein type: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity

Biological Process: synaptic transmission
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Research Articles on PDE7B

1. PDE7B polymorphisms were not associated with schizophrenia risk.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PDE7B active protein

 Reference Product  PubMed Publications
 ADCY9 active protein  >1 publications with PDE7B and ADCY9
 ADCY3 active protein  >1 publications with PDE7B and ADCY3

Pathways associated with PDE7B active protein

 Products by Pathway  Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with PDE7B active protein

 Disease Name  Pubmed Publications
 Anemia Antibodies  >2 publications with PDE7B and Anemia
 Brain Diseases Antibodies  >2 publications with PDE7B and Brain Diseases
 Inflammation Antibodies  >2 publications with PDE7B and Inflammation
 Neurologic Manifestations Antibodies  >1 publications with PDE7B and Neurologic Manifestations
 Neurobehavioral Manifestations Antibodies  >1 publications with PDE7B and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >1 publications with PDE7B and Learning Disorders
 Hyperplasia Antibodies  >1 publications with PDE7B and Hyperplasia

Organs/Tissues associated with PDE7B active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with PDE7B and Brain
 Muscle Antibodies  >3 publications with PDE7B and Muscle
 Eye Antibodies  >2 publications with PDE7B and Eye
 Ganglia Antibodies  >1 publications with PDE7B and Ganglia
 Prostate Antibodies  >1 publications with PDE7B and Prostate
 Lung Antibodies  >1 publications with PDE7B and Lung
 Uncharacterized Tissue Antibodies  >1 publications with PDE7B and Uncharacterized Tissue
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