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RAC3 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515647

Description: Recombinant full length human RAC3 was expressed in E Coli cells using an N-terminal His tag.Scientific Background: RAC3 is a GTPase which belongs to the RHO family of small GTP-binding proteins that regulate a diverse array of cellular events,… More details

$370 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RAC3, Recombinant Protein
Full Product Name
RAC3, Active
Product Gene Name
RAC3 recombinant protein
Host
E Coli
Form/Format
50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
24 kDa
Sequence Positions
Full length
OMIM
AF008591 mRNA
3D Structure
ModBase 3D Structure for P60763
Species
Human
Tag
HIS tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for RAC3 recombinant protein

Enzymes; Active GTPases/ATPases
Applications Tested/Suitable for RAC3 recombinant protein
Enzyme Assay, Western Blot (WB)

Testing Data of RAC3 recombinant protein

RAC3 Recombinant Protein – Cat# MBS515647

Testing Data #2 of RAC3 recombinant protein

RAC3 Recombinant Protein, Testing Data #2 – Cat# MBS515647

Product References and Citations for RAC3 recombinant protein

1. Hajdo-Milasinovic A, et al: Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling. J Cell Sci. 2009 Jun 15;122 (Pt 12):2127-36. 2. Lozano E, et al: PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac. J Cell Sci. 2008 Apr 1;121 (Pt 7):933-8.

Other Notes

Small volumes of RAC3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAC3 purchase

MBS515647 is a recombinant protein targeting RAC3. Also known as RAC3, Active. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for RAC3. It may not necessarily be applicable to this product.

NCBI GI #
38683861
NCBI GeneID
5881
NCBI Accession #
NM_005052.2
UniProt Primary Accession #
P60763
UniProt Secondary Accession #
O14658; Q5U0M8
UniProt Related Accession #
P60763
GenBank Nucleotide #
NM_005052
NCBI Official Full Name
Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), transcript variant 1, mRNA
NCBI Official Synonym Full Names
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
NCBI Official Symbol
RAC3
UniProt Protein Name
Ras-related C3 botulinum toxin substrate 3
UniProt Synonym Protein Names
p21-Rac3
Protein Family
Rac-like GTP-binding protein
UniProt Gene Name
RAC3
NCBI Protein Information
ras-related C3 botulinum toxin substrate 3

NCBI Summary for RAC3

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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UniProt Comments for RAC3

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.
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Research Articles on RAC3

1. Rac3 regulates the biological behaviors of lung adenocarcinoma through a mechanism of downregulating CCND1, MYC, and TFDP1 of cell cycle pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RAC3 recombinant protein

 Reference Product  PubMed Publications
 SRC recombinant protein  >37 publications with RAC3 and SRC
 TIAM1 recombinant protein  >4 publications with RAC3 and TIAM1
 PLXNB1 recombinant protein  >1 publications with RAC3 and PLXNB1
 VAV1 recombinant protein  >1 publications with RAC3 and VAV1

Pathways associated with RAC3 recombinant protein

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram

Diseases associated with RAC3 recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >18 publications with RAC3 and Breast Neoplasms
 Necrosis Antibodies  >7 publications with RAC3 and Necrosis
 Neoplasms, Experimental Antibodies  >7 publications with RAC3 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >5 publications with RAC3 and Cell Transformation, Neoplastic
 Immune System Diseases Antibodies  >5 publications with RAC3 and Immune System Diseases
 Disease Models, Animal Antibodies  >4 publications with RAC3 and Disease Models, Animal
 Nervous System Diseases Antibodies  >4 publications with RAC3 and Nervous System Diseases
 Adenocarcinoma Antibodies  >4 publications with RAC3 and Adenocarcinoma
 Mammary Neoplasms, Animal Antibodies  >2 publications with RAC3 and Mammary Neoplasms, Animal
 Immunologic Deficiency Syndromes Antibodies  >2 publications with RAC3 and Immunologic Deficiency Syndromes

Organs/Tissues associated with RAC3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >13 publications with RAC3 and Prostate
 Brain Antibodies  >12 publications with RAC3 and Brain
 Blood Antibodies  >11 publications with RAC3 and Blood
 Liver Antibodies  >6 publications with RAC3 and Liver
 Nerve Antibodies  >5 publications with RAC3 and Nerve
 Mammary Gland Antibodies  >5 publications with RAC3 and Mammary Gland
 Lung Antibodies  >3 publications with RAC3 and Lung
 Lymph Antibodies  >3 publications with RAC3 and Lymph
 Stomach Antibodies  >2 publications with RAC3 and Stomach
 Intestine Antibodies  >1 publications with RAC3 and Intestine
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