Mouse Anti-CD8b Monoclonal Antibody – Cat# MBS520236

CD8b Antibody – Mouse Monoclonal

Name: CD8b Antibody; Monoclonal; Mouse; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS520236
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS520236

anti-rat CD8b monoclonal antibody reacts with the beta chain of the CD8 differentiation antigen. CD8b is expressed on most thymocytes and mature T cytotoxic/ suppressor cells (MHC class I restricted). While the CD8a and CD8b form a heterodimer on the surface… More details

$365 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD8b, Monoclonal Antibody

Full Product Name

Anti-Rat CD8b PE (Clone 3.4.1) (mouse IgG1)

Product Gene Name

anti-CD8b antibody

Product Synonym Names

CD8b PE (Clone 3.4.1) (mouse IgG1); PE Anti-Rat CD8b Monoclonal Antibody

Clonality

Monoclonal

Isotype

mouse IgG1,K

Clone Number

3.4.1

Host

Mouse

Species Reactivity

Rat

Form/Format

PE (R-PE conjugated Ig buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. (Purified from ascitic fluid via Protein G Chromatography))

Concentration

Antibody Concentration: 0.1 mg/ml (lot specific)

Specificity

CD8b (á chain) (Rat CD8b)

Preparation and Storage

Store at 4 degree C. DO NOT FREEZE. Avoid prolonged exposure to light.

Chromosome Location

Chromosome: 2; NC_000002.11 (87042460..87089047, complement). Location: 2p12

Immunogen

Rat/mouse T cell hybrids expressing CD8

Donor

BALB/c mouse spleen cells

Fusion Partner

X63 Ag.653 myeloma cell line

Presentation

50 ug or 200ug R-PE conjugated Ig buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.

Applications Tested/Suitable for anti-CD8b antibody

Immunohistochemistry (IHC)

Other Notes

Small volumes of anti-CD8b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD8b purchase

MBS520236 is an antibody targeting CD8b. Also known as Anti-Rat CD8b PE (Clone 3.4.1) (mouse IgG1). Reactive in Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD8b. It may not necessarily be applicable to this product.

NCBI GI #

71682667

NCBI GeneID

926

NCBI Accession #

AAI00912.1

UniProt Related Accession #

P10966

NCBI Official Full Name

CD8b molecule

NCBI Official Synonym Full Names

CD8b molecule

NCBI Official Symbol

CD8B

NCBI Official Synonym Symbols

LY3; P37; LEU2; LYT3; CD8B1

Protein Family

T-cell surface glycoprotein

NCBI Protein Information

T-cell surface glycoprotein CD8 beta chain; CD8 antigen, beta polypeptide 1 (p37); T lymphocyte surface glycoprotein beta chain

NCBI Summary for CD8b

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

UniProt Comments for CD8b

CD8B: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome membrane; extracellular region; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; MHC class I protein binding; coreceptor activity

Biological Process: regulation of immune response; viral reproduction; T cell activation; immune response; regulation of defense response to virus by virus; transmembrane receptor protein tyrosine kinase signaling pathway

Research Articles on CD8b

1. Nef-mediated down-modulation of CD8alphabeta is a fundamental property of primate lentiviruses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD8b antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signaling In Naive CD8+ T Cells Pathway antibodies	Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
HIV Infection Pathway antibodies	HIV Infection Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-CD8b antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with CD8b and Neoplasms
Disease Models, Animal Antibodies	>2 publications with CD8b and Disease Models, Animal
Necrosis Antibodies	>1 publications with CD8b and Necrosis
Liver Diseases Antibodies	>1 publications with CD8b and Liver Diseases

Organs/Tissues associated with anti-CD8b antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>26 publications with CD8b and Blood
Thymus Antibodies	>6 publications with CD8b and Thymus
Lymph Node Antibodies	>4 publications with CD8b and Lymph Node
Trachea Antibodies	>1 publications with CD8b and Trachea
Intestine Antibodies	>1 publications with CD8b and Intestine
Lung Antibodies	>1 publications with CD8b and Lung