Human LGI1 cDNA Clone Expression Plasmid – Cat# MBS1269167

LGI1 cDNA Clone – Leucine-Rich, Glioma Inactivated 1 (Human)

Name: LGI1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269167
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269167

MBS1269167 is a cDNA clone targeting LGI1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LGI1, cDNA Clone

Full Product Name

LGI1 cDNA Clone

Product Gene Name

LGI1 cdna clone

Sequence

atggaatcag aaagaagcaa aaggatggga aatgcctgca ttcccctgaa aagaattgct tatttcctat gtctcttatc tgcgcttttg ctgactgagg ggaagaaacc agcgaagcca aaatgccctg ccgtgtgtac ttgtaccaaa gataatgctt tatgtgagaa tgccagatcc attccacgca ccgttcctcc tgatgttatc tcattatcct ttgtgagatc tggttttact gaaatctcag aagggagttt tttattcacg ccatcgctgc agctcttgtt attcacatcg aactcctttg atgtgatcag tgatgatgct tttattggtc ttccacatct agagtattta ttcatagaaa acaacaacat caagtcaatt tcaagacata ctttccgggg actaaagtca ttaattcact tgagccttgc aaacaacaat ctccagacac tcccaaaaga tattttcaaa ggcctggatt ctttaacaaa tgtggacctg aggggtaatt catttaattg tgactgtaaa ctgaaatggc tagtggaatg gcttggccac accaatgcaa ctgttgaaga catctactgc gaaggccccc cagaatacaa gaagcgcaaa atcaatagtc tctcctcgaa ggatttcgat tgcatcatta cagaatttgc aaagtctcaa gacctgcctt atcaatcatt gtccatagac actttttctt atttgaatga tgagtatgta gtcatcgctc agccttttac tggaaaatgc attttccttg aatgggacca tgtggaaaag accttccgga attatgacaa cattacaggc acatccactg tagtatgcaa gcctatagtc attgaaactc agctctatgt tattgtggcc cagctgtttg gtggctctca catctataag cgagacagtt ttgcaaataa attcataaaa atccaggata ttgaaattct caaaatccga aaacccaatg acattgaaac attcaagatt gaaaacaact ggtactttgt tgttgctgac agttcaaaag ctggttttac taccatttac aaatggaacg gaaacggatt ctactcccat caatccttac acgcgtggta cagggacact gatgtggaat atctagaaat agtcagaaca cctcagacac tcagaacgcc tcatttaatt ctgtctagta gttcccagcg tcctgtaatt tatcagtgga acaaagcaac acaattattc actaaccaaa ctgacattcc taacatggag gatgtgtacg cagtgaagca cttctcagtg aaaggggacg tgtacatttg cttgacaaga ttcattggtg attccaaagt catgaaatgg ggaggctcct cgttccagga tattcagagg atgccatcgc gaggatccat ggtgttccag cctcttcaaa taaataatta ccaatatgca attcttggaa gtgattactc ctttactcaa gtgtataact gggatgcaga gaaagccaaa tttgtgaaat ttcaggaatt aaatgttcag gcaccaagat cattcacaca tgtgtccatt aataagcgta attttctttt tgcttccagt tttaagggaa atacacagat ttacaaacat gtcatagttg acttaagcgc atga

Molecular Weight

58,302 Da

OMIM

600512

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LGI1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LGI1. It may not necessarily be applicable to this product.

NCBI GI #

18490909

NCBI GeneID

9211

NCBI Accession #

BC022500

UniProt Secondary Accession #

Q5W001; Q5W002; Q8NI23; Q96LF5; A8K0Z1; B4E1S0

UniProt Related Accession #

O95970

NCBI Official Full Name

Homo sapiens leucine-rich, glioma inactivated 1, mRNA

NCBI Official Synonym Full Names

leucine rich glioma inactivated 1

NCBI Official Symbol

LGI1

NCBI Official Synonym Symbols

EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN

UniProt Protein Name

Leucine-rich glioma-inactivated protein 1

UniProt Synonym Protein Names

Epitempin-1

Protein Family

Leucine-rich glioma-inactivated protein

UniProt Gene Name

LGI1

UniProt Synonym Gene Names

EPT

UniProt Entry Name

LGI1_HUMAN

NCBI Protein Information

leucine-rich glioma-inactivated protein 1

NCBI Summary for LGI1

This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

UniProt Comments for LGI1

LGI1: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. Defects in LGI1 are the cause of epilepsy, familial temporal lobe, type 1 (ETL1). A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: extracellular region

Molecular Function: protein binding; receptor binding

Biological Process: axon guidance; cell proliferation; nervous system development; neurite development; positive regulation of cell growth; positive regulation of synaptic transmission

Disease: Epilepsy, Familial Temporal Lobe, 1

Research Articles on LGI1

1. Report of three novel LGI1 mutations, a microdeletion of exon 2 and two missense mutations in exon 8, occurring in two autosomal dominant lateral temporal epilepsy families and in one sporadic patient with lateral temporal epilepsy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with LGI1 cdna clone

Disease Name	Pubmed Publications
Glioma Antibodies	>78 publications with LGI1 and Glioma
Neoplasms Antibodies	>35 publications with LGI1 and Neoplasms
Neurobehavioral Manifestations Antibodies	>14 publications with LGI1 and Neurobehavioral Manifestations
Congenital Abnormalities Antibodies	>8 publications with LGI1 and Congenital Abnormalities
Carcinoma Antibodies	>4 publications with LGI1 and Carcinoma
Disease Models, Animal Antibodies	>4 publications with LGI1 and Disease Models, Animal
Nervous System Malformations Antibodies	>2 publications with LGI1 and Nervous System Malformations
Neoplasms, Experimental Antibodies	>1 publications with LGI1 and Neoplasms, Experimental
Edema Antibodies	>1 publications with LGI1 and Edema
Intestinal Neoplasms Antibodies	>1 publications with LGI1 and Intestinal Neoplasms

Organs/Tissues associated with LGI1 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>79 publications with LGI1 and Brain
Nerve Antibodies	>39 publications with LGI1 and Nerve
Ganglia Antibodies	>8 publications with LGI1 and Ganglia
Muscle Antibodies	>6 publications with LGI1 and Muscle
Embryonic Tissue Antibodies	>5 publications with LGI1 and Embryonic Tissue
Kidney Antibodies	>4 publications with LGI1 and Kidney
Eye Antibodies	>2 publications with LGI1 and Eye
Testis Antibodies	>1 publications with LGI1 and Testis