Transglutaminase 2, Tissue (TGM2) ELISA Kit for Mouse

Name: Mouse TGM2 ELISA Kit; Transglutaminase 2, Tissue; MyBioSource
Brand: MyBioSource
SKU: MBS052665
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS052665

Background: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used to determine the level of TGM2 (hereafter termed "analyte") in undiluted original… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Transglutaminase 2, Tissue (TGM2), ELISA Kit

Full Product Name

Mouse Transglutaminase 2, Tissue ELISA Kit

Product Gene Name

TGM2 elisa kit

Species Reactivity

Mouse

Assay Type

Quantitative Sandwich

Detection Range

0.625ng/ml-20ng/ml

Sensitivity

0.1ng/ml

Specificity

No significant cross-reactivity or interference between Mouse TGM2 and analogues was observed.

Preparation and Storage

Store all reagents at 2-8 degree C

Inter-assay Precision

Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Intra-assay Precision

Intra-assay CV (%) is less than 15%.

Molecular Weight

77,329 Da

OMIM

190196

3D Structure

ModBase 3D Structure for P21980

Other Notes

Small volumes of TGM2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGM2 purchase

MBS052665 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Transglutaminase 2, Tissue (TGM2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TGM2. The ELISA analytical biochemical technique of the MBS052665 kit is based on TGM2 antibody-TGM2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TGM2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TGM2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for TGM2. It may not necessarily be applicable to this product.

NCBI GI #

50593093

NCBI GeneID

7052

NCBI Accession #

AAT79353.1

UniProt Primary Accession #

P21980

UniProt Secondary Accession #

Q16436; Q6B838; Q9BTN7; Q9UH35; E1P5V9

UniProt Related Accession #

P21980

NCBI Official Full Name

transglutaminase 2

NCBI Official Synonym Full Names

transglutaminase 2

NCBI Official Symbol

TGM2

NCBI Official Synonym Symbols

TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h

UniProt Protein Name

Protein-glutamine gamma-glutamyltransferase 2

UniProt Synonym Protein Names

Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2

Protein Family

Protein-glutamine gamma-glutamyltransferase

UniProt Gene Name

TGM2

UniProt Synonym Gene Names

TG(C); TGC; TGase C; TGase H; TGase-2

UniProt Entry Name

TGM2_HUMAN

NCBI Protein Information

protein-glutamine gamma-glutamyltransferase 2; TG(C); TGase C; TGase H; TGase-2; TGase-H; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; epididymis secretory protein Li 45; protein-glutamine-gamma-glutamyltransferase; C polypeptide, protein-glutamine-gamma-glutamyltransferase

NCBI Summary for TGM2

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for TGM2

TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.

Protein type: Transferase; EC 2.3.2.13

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: focal adhesion; mitochondrion; plasma membrane; cytosol

Molecular Function: protein domain specific binding; protein binding; GTP binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell adhesion; positive regulation of apoptosis; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of smooth muscle cell proliferation; blood vessel remodeling; protein homooligomerization; apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; positive regulation of inflammatory response

Research Articles on TGM2

1. Accumulation of TG2 in tumor stroma is an independent risk factor for identifying breast cancer patients at high risk of recurrence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGM2 elisa kit

Reference Product	PubMed Publications
ITGB1 elisa kit	>1 publications with TGM2 and ITGB1
FN1 elisa kit	>1 publications with TGM2 and FN1

Pathways associated with TGM2 elisa kit

Products by Pathway	Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Thromboxane A2 Receptor Signaling Pathway antibodies	Thromboxane A2 Receptor Signaling Pathway Diagram

Diseases associated with TGM2 elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>27 publications with TGM2 and Neoplasms
Inflammation Antibodies	>8 publications with TGM2 and Inflammation
Lung Neoplasms Antibodies	>6 publications with TGM2 and Lung Neoplasms
Necrosis Antibodies	>5 publications with TGM2 and Necrosis
Cardiovascular Diseases Antibodies	>5 publications with TGM2 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>5 publications with TGM2 and Breast Neoplasms
Fibrosis Antibodies	>4 publications with TGM2 and Fibrosis
Brain Neoplasms Antibodies	>4 publications with TGM2 and Brain Neoplasms
Carcinoma, Hepatocellular Antibodies	>4 publications with TGM2 and Carcinoma, Hepatocellular
Ovarian Neoplasms Antibodies	>3 publications with TGM2 and Ovarian Neoplasms

Organs/Tissues associated with TGM2 elisa kit

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>10 publications with TGM2 and Lung
Liver Antibodies	>9 publications with TGM2 and Liver
Blood Antibodies	>9 publications with TGM2 and Blood
Brain Antibodies	>9 publications with TGM2 and Brain
Eye Antibodies	>7 publications with TGM2 and Eye
Bone Antibodies	>7 publications with TGM2 and Bone
Skin Antibodies	>7 publications with TGM2 and Skin
Connective Tissue Antibodies	>5 publications with TGM2 and Connective Tissue
Vascular Antibodies	>5 publications with TGM2 and Vascular
Muscle Antibodies	>5 publications with TGM2 and Muscle