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MRP1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS531429

MBS531429 is an antibody targeting MRP1. Also known as MRP1 antibody. Host: Mouse. Mouse monoclonal MRP1 antibody More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MRP1, Monoclonal Antibody
Full Product Name
MRP1 antibody
Product Gene Name
anti-MRP1 antibody
Product Synonym Names
Monoclonal MRP1; Anti-MRP1; MRP-1; MRP 1; MRP1; Multidrug resistance related Protein
Clonality
Monoclonal
Isotype
IgG1
Clone Number
MRPm6
Host
Mouse
Form/Format
Cupplied as cell culture supernatant with 1% BSA and 0.1% NaN3
Purity/Purification
Culture supernatant
Specificity
Human MRP1
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
170,496 Da
3D Structure
ModBase 3D Structure for Q8CG09
Cross-Reactivity
This antibody recognizes an internal epitope of MRP1
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
MRP1 antibody was raised in mouse using fusion protein containing the C-terminus with part of the carboxy-proximal nucleotide-binding domain of MRP1 protein as the immunogen.

Product Categories/Family for anti-MRP1 antibody

Cell Biology
Applications Tested/Suitable for anti-MRP1 antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Flow Cytometry (FC/FACS)
Application Notes for anti-MRP1 antibody
IHC-F: 1:20-1:50
IHC-P: 1:20-1:50

Other Notes

Small volumes of anti-MRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MRP1. It may not necessarily be applicable to this product.

NCBI GI #
31542029
NCBI GeneID
24565
NCBI Accession #
NP_071617.2
UniProt Primary Accession #
Q8CG09
UniProt Secondary Accession #
Q63346; Q810E4; Q810G9; Q9JHS0
UniProt Related Accession #
Q8CG09
GenBank Nucleotide #
NM_022281.2
NCBI Official Full Name
multidrug resistance-associated protein 1
NCBI Official Synonym Full Names
ATP-binding cassette, subfamily C (CFTR/MRP), member 1
NCBI Official Symbol
Abcc1
NCBI Official Synonym Symbols
Mrp; Mrp1; Abcc1a; Avcc1a
UniProt Protein Name
Multidrug resistance-associated protein 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter
Protein Family
37S ribosomal protein
UniProt Gene Name
Abcc1
UniProt Synonym Gene Names
Mrp1; LTC4 transporter
UniProt Entry Name
MRP1_RAT
NCBI Protein Information
multidrug resistance-associated protein 1

NCBI Summary for MRP1

ATP-binding cassette (ABC) multiple drug resistance protein involved in the release of glutathione synthase during oxidative stress [RGD, Feb 2006]

UniProt Comments for MRP1

ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, ABC family

Cellular Component: membrane; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane

Molecular Function: lipid-transporting ATPase activity; efflux transmembrane transporter activity; ATPase activity, coupled to transmembrane movement of substances; ATPase activity; sphingolipid transporter activity; long-chain fatty acid transporter activity; oxidoreductase activity; drug transporter activity; glutathione S-conjugate-exporting ATPase activity; ATP binding; xenobiotic-transporting ATPase activity

Biological Process: response to drug; daunorubicin transport; phospholipid efflux; drug export; xenobiotic transport; multidrug transport; response to oxidative stress; plasma membrane long-chain fatty acid transport; transmembrane transport; positive regulation of cell migration
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Research Articles on MRP1

1. Sonication enhanced sensitivity of glioma tumor cells to doxorubicin by down-regulating the expressions of p-glycoprotein and multidrug resistance protein 1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MRP1 antibody

 Reference Product  PubMed Publications
 Abcg2 antibody  >270 publications with MRP1 and Abcg2
 Abcg1 antibody  >12 publications with MRP1 and Abcg1
 Abca2 antibody  >9 publications with MRP1 and Abca2
 Abca7 antibody  >9 publications with MRP1 and Abca7
 Abcg8 antibody  >6 publications with MRP1 and Abcg8
 Slc22a8 antibody  >4 publications with MRP1 and Slc22a8
 Notch1 antibody  >2 publications with MRP1 and Notch1
 Spns2 antibody  >1 publications with MRP1 and Spns2

Pathways associated with anti-MRP1 antibody

 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Irinotecan Pathway antibodies  Irinotecan Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 NFE2L2 Pathway antibodies  NFE2L2 Pathway Diagram
 Relationship Between Glutathione And NADPH Pathway antibodies  Relationship Between Glutathione And NADPH Pathway Diagram
 Sphingolipid Signaling Pathway antibodies  Sphingolipid Signaling Pathway Diagram
 Sphingolipid Signaling Pathway antibodies  Sphingolipid Signaling Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram

Diseases associated with anti-MRP1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >51 publications with MRP1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >32 publications with MRP1 and Lung Neoplasms
 Brain Diseases Antibodies  >28 publications with MRP1 and Brain Diseases
 Nervous System Diseases Antibodies  >28 publications with MRP1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >27 publications with MRP1 and Adenocarcinoma
 Liver Diseases Antibodies  >23 publications with MRP1 and Liver Diseases
 Disease Models, Animal Antibodies  >20 publications with MRP1 and Disease Models, Animal
 Disease Progression Antibodies  >18 publications with MRP1 and Disease Progression
 Ovarian Neoplasms Antibodies  >16 publications with MRP1 and Ovarian Neoplasms
 Liver Neoplasms Antibodies  >16 publications with MRP1 and Liver Neoplasms

Organs/Tissues associated with anti-MRP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >78 publications with MRP1 and Brain
 Liver Antibodies  >66 publications with MRP1 and Liver
 Kidney Antibodies  >49 publications with MRP1 and Kidney
 Prostate Antibodies  >8 publications with MRP1 and Prostate
 Ovary Antibodies  >7 publications with MRP1 and Ovary
 Embryonic Tissue Antibodies  >7 publications with MRP1 and Embryonic Tissue
 Thymus Antibodies  >4 publications with MRP1 and Thymus
 Eye Antibodies  >4 publications with MRP1 and Eye
 Pancreas Antibodies  >2 publications with MRP1 and Pancreas
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