ARF4 Antibody – Rabbit Polyclonal

This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]

ARF4: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, ARF; G protein

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: Golgi apparatus; membrane; cytosol

Molecular Function: GTPase activity; protein binding; GTP binding; epidermal growth factor receptor binding

Biological Process: vesicle-mediated transport; epidermal growth factor receptor signaling pathway; phospholipase D activation; protein transport; cell migration; protein amino acid ADP-ribosylation; small GTPase mediated signal transduction; organelle organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; brain development; response to axon injury; negative regulation of apoptosis