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ADI1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS533219

MBS533219 is an antibody targeting ADI1. Also known as ADI1 antibody. Host: Mouse. Mouse monoclonal ADI1 antibody More details

$1615 / 0.1 mL +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ADI1, Monoclonal Antibody
Full Product Name
ADI1 antibody
Product Gene Name
anti-ADI1 antibody
Product Synonym Names
Monoclonal ADI1; Anti-ADI1; Acireductone dioxygenase; Acireductone dioxygenase 1; SIPL; ARD; APL1; FLJ10913; MTCBP1; MTCBP-1; Submergence induced protein 2; ADI1; ADI 1; ADI-1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3H6
Host
Mouse
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purity/Purification
ADI1 antibody was purified by affinity chromatography.
Concentration
500 ug-1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
20,332 Da
OMIM
613400
3D Structure
ModBase 3D Structure for Q9BV57
Cross-Reactivity
Human
Immunogen
ADI1 antibody was raised in mouse using a full length recombinant protein of human ADI1 (NP_060739) produced in HEK293T cells, as the immunogen.

Product Categories/Family for anti-ADI1 antibody

Proteases; Inhibitors; & Enzymes
Applications Tested/Suitable for anti-ADI1 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-ADI1 antibody
IF: 1:100
FC: 1:100
WB: 1:500

Western Blot (WB) of anti-ADI1 antibody

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ADI1 protein (Right) or empty vector (Left) detected with ADI1 antibody
Mouse Anti-ADI1 Monoclonal Antibody – Cat# MBS533219

Immunofluorescence (IF) of anti-ADI1 antibody

Immunofluorescent staining of COS7 cells transiently transfected with recombinant ADI1 protein using ADI1 antibody
Mouse Anti-ADI1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS533219

Other Notes

Small volumes of anti-ADI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ADI1. It may not necessarily be applicable to this product.

NCBI GI #
171460928
NCBI GeneID
55256
NCBI Accession #
NP_060739
UniProt Primary Accession #
Q9BV57
UniProt Secondary Accession #
Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9NV57; D6W4Y3
UniProt Related Accession #
Q9BV57
GenBank Nucleotide #
NM_018269.3
NCBI Official Full Name
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase isoform 1
NCBI Official Synonym Full Names
acireductone dioxygenase 1
NCBI Official Symbol
ADI1
NCBI Official Synonym Symbols
ARD; APL1; SIPL; mtnD; Fe-ARD; MTCBP1; Ni-ARD; HMFT1638
UniProt Protein Name
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
UniProt Synonym Protein Names
Acireductone dioxygenase (Fe(2+)-requiring)
Protein Family
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
UniProt Gene Name
ADI1
UniProt Synonym Gene Names
ARD; Fe-ARD; MTCBP-1; Sip-L
UniProt Entry Name
MTND_HUMAN
NCBI Protein Information
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

NCBI Summary for ADI1

This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
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UniProt Comments for ADI1

ADI1: Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. Belongs to the acireductone dioxygenase (ARD) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - cysteine and methionine; Oxidoreductase; EC 1.13.11.54

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: acireductone dioxygenase [iron(II)-requiring] activity; protein binding; iron ion binding; oxidoreductase activity

Biological Process: methionine salvage; sulfur amino acid metabolic process; polyamine metabolic process
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Research Articles on ADI1

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ADI1 antibody

 Products by Pathway  Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Polyamines Pathway antibodies  Metabolism Of Polyamines Pathway Diagram
 Methionine Salvage Pathway antibodies  Methionine Salvage Pathway Diagram
 Methionine Salvage Pathway antibodies  Methionine Salvage Pathway Diagram
 Methionine Salvage Pathway antibodies  Methionine Salvage Pathway Diagram
 S-methyl-5-thio-alpha-D-ribose 1-phosphate Degradation Pathway antibodies  S-methyl-5-thio-alpha-D-ribose 1-phosphate Degradation Pathway Diagram

Diseases associated with anti-ADI1 antibody

 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >2 publications with ADI1 and Hyperplasia
 Liver Diseases Antibodies  >1 publications with ADI1 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with ADI1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with ADI1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with ADI1 and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with ADI1 and Disease Models, Animal
 Prostatic Neoplasms Antibodies  >1 publications with ADI1 and Prostatic Neoplasms

Organs/Tissues associated with anti-ADI1 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >2 publications with ADI1 and Prostate
 Liver Antibodies  >1 publications with ADI1 and Liver
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