Rat MIP-1 alpha Active Protein – Cat# MBS691838

MIP-1 alpha Rat Active Protein

Name: MIP-1 alpha Active Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS691838
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691838

Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MIP-1 alpha, Active Protein

Full Product Name

Rat MIP-1 alpha

Product Gene Name

MIP-1 alpha active protein

Product Synonym Names

Recombinant Rat MIP-1alpha

Sequence

APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRN RQIC ADPKETWVQE YITELELNA

Host

E Coli

Species Reactivity

Rat

Form/Format

Lyophilized

Purity/Purification

> 95% (SDS-PAGE; HPLC)

Molecular Weight

8.0 kDa

Chromosome Location

Chromosome: 10; NC_005109.3 (70501119..70502669, complement). Location: 10q26

3D Structure

ModBase 3D Structure for P50229

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng/ug of MIP-1alpha

Biological Activity

Assay#1: Determined by its ability to chemoattract rat peritoneal macrophages using a concentration of 50.0-100.0 ng/ml. Assay#2: Determined by its ability to chemoattract human blood monocytes using a concentration range of 10.0-100.0 ng/ml.

Product Categories/Family for MIP-1 alpha active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of MIP-1 alpha active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP-1 alpha purchase

MBS691838 is an active protein targeting MIP-1 alpha. Also known as Rat MIP-1 alpha. Reactive in Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP-1 alpha. It may not necessarily be applicable to this product.

NCBI GI #

40254794

NCBI GeneID

25542

NCBI Accession #

NP_037157.2

UniProt Primary Accession #

P50229

UniProt Secondary Accession #

A1EC87

UniProt Related Accession #

P50229

GenBank Nucleotide #

NM_013025.2

NCBI Official Full Name

C-C motif chemokine 3

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 3

NCBI Official Symbol

Ccl3

NCBI Official Synonym Symbols

Scya3; MIP-1a

UniProt Protein Name

C-C motif chemokine 3

UniProt Synonym Protein Names

Macrophage inflammatory protein 1-alpha; MIP-1-alpha; Small-inducible cytokine A3

Protein Family

C-C motif chemokine

UniProt Gene Name

Ccl3

UniProt Synonym Gene Names

Mip1a; Scya3; MIP-1-alpha

UniProt Entry Name

CCL3_RAT

NCBI Protein Information

C-C motif chemokine 3; MIP-1-alpha; small inducible cytokine A3; small-inducible cytokine A3; macrophage inflammatory protein 1-alpha; Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3)

NCBI Summary for MIP-1 alpha

mediates monocyte and neutrophil chemotaxis; may play a role in the pathogenesis of acute lung injury [RGD, Feb 2006]

UniProt Comments for MIP-1 alpha

Function: Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin.

Subcellular location: Secreted.

Induction: By lipopolysaccharide (LPS).

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Research Articles on MIP-1 alpha

1. NMDA-evoked neuronal injury differentially induces MIP-1alpha and MCP-1 production in microglia and astrocytes, respectively, through activation of different intracellular signaling pathways.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MIP-1 alpha active protein

Products by Pathway	Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with MIP-1 alpha active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>796 publications with MIP-1 alpha and Inflammation
Necrosis Antibodies	>468 publications with MIP-1 alpha and Necrosis
Disease Models, Animal Antibodies	>287 publications with MIP-1 alpha and Disease Models, Animal
Lung Diseases Antibodies	>221 publications with MIP-1 alpha and Lung Diseases
HIV Infections Antibodies	>184 publications with MIP-1 alpha and HIV Infections
Cardiovascular Diseases Antibodies	>156 publications with MIP-1 alpha and Cardiovascular Diseases
Hypersensitivity Antibodies	>100 publications with MIP-1 alpha and Hypersensitivity
Liver Diseases Antibodies	>83 publications with MIP-1 alpha and Liver Diseases
Pneumonia Antibodies	>67 publications with MIP-1 alpha and Pneumonia
Fibrosis Antibodies	>66 publications with MIP-1 alpha and Fibrosis

Organs/Tissues associated with MIP-1 alpha active protein

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>30 publications with MIP-1 alpha and Connective Tissue
Adipose Tissue Antibodies	>18 publications with MIP-1 alpha and Adipose Tissue
Inner Ear Antibodies	>1 publications with MIP-1 alpha and Inner Ear