Calsequestrin (CASQ1) Antibody – Rabbit Polyclonal

calsequestrin 1: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+). Belongs to the calsequestrin family.

Protein type: Mitochondrial; Calcium-binding

Cellular Component: I band; Golgi apparatus; sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; mitochondrion; sarcoplasmic reticulum; intracellular membrane-bound organelle; myofibril; T-tubule; mitochondrial matrix; cytoplasm; intracellular; sarcolemma

Molecular Function: calcium ion binding

Biological Process: protein polymerization; endoplasmic reticulum organization and biogenesis; response to organic substance; regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; regulation of sequestering of calcium ion; skeletal muscle development; response to heat; sarcomere organization; response to denervation involved in regulation of muscle adaptation; response to muscle inactivity