PDE3A Antibody – Rabbit Polyclonal

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

PDE3A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Inhibited by cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.

Protein type: EC 3.1.4.17; Membrane protein, multi-pass; Membrane protein, integral; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: integral to membrane; cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; metal ion binding; cAMP binding

Biological Process: response to drug; diterpenoid metabolic process; cAMP-mediated signaling; response to cAMP; cGMP-mediated signaling; cAMP catabolic process; negative regulation of vascular permeability; regulation of meiosis; lipid metabolic process; blood coagulation; oocyte maturation; positive regulation of vascular permeability; negative regulation of apoptosis

Disease: Hypertension And Brachydactyly Syndrome