Sonic Hedgehog (SHH) Active Protein

SHH: Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus. N-product is active as a multimer. Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues. Belongs to the hedgehog family.

Protein type: Oncoprotein; Cell cycle regulation; Cell development/differentiation; Motility/polarity/chemotaxis

Cellular Component: Golgi apparatus; extracellular space; cell surface; endoplasmic reticulum; dendrite; extracellular region; lipid raft; proteinaceous extracellular matrix; transport vesicle; cell soma; membrane; axon; plasma membrane; nucleus

Molecular Function: laminin-1 binding; peptidase activity; protein binding; glycosaminoglycan binding; hydrolase activity; zinc ion binding; metal ion binding; patched binding; calcium ion binding; glycoprotein binding

Biological Process: skin development; prostate gland development; developmental growth; central nervous system development; embryonic skeletal development; positive regulation of transcription, DNA-dependent; mesenchymal cell proliferation; telencephalon regionalization; positive regulation of mesenchymal cell proliferation; embryonic foregut morphogenesis; male genitalia development; anatomical structure formation; oligodendrocyte differentiation; kidney development; inner ear development; neural crest cell migration; embryonic limb morphogenesis; hindbrain development; positive regulation of neuroblast proliferation; tongue morphogenesis; cell fate commitment; camera-type eye development; neuron fate commitment; myotube differentiation; intermediate filament organization; osteoblast development; positive regulation of skeletal muscle cell proliferation; response to ethanol; regulation of gene expression; positive regulation of photoreceptor cell differentiation; positive regulation of cell division; regulation of proteolysis; embryonic organ development; striated muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; determination of left/right symmetry; negative regulation of protein catabolic process; neural tube formation; negative regulation of apoptosis; embryonic forelimb morphogenesis; limb development; axon guidance; granule cell precursor proliferation; spinal cord dorsal/ventral patterning; palate development; thalamus development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of striated muscle cell differentiation; signal transduction; Bergmann glial cell differentiation; negative regulation of T cell proliferation; forebrain development; pancreas development; positive regulation of cell proliferation; thyroid gland development; heart looping; embryonic morphogenesis; angiogenesis; ventral spinal cord interneuron specification; vasculogenesis; negative regulation of cell migration; positive regulation of granule cell precursor proliferation; positive thymic T cell selection; gut mesoderm development; intein-mediated protein splicing; regulation of odontogenesis; androgen metabolic process; spinal cord motor neuron differentiation; pattern specification process; regulation of cell proliferation; odontogenesis of dentine-containing teeth; cell proliferation; stem cell development; embryonic development; negative regulation of cell differentiation; dorsal/ventral pattern formation; positive regulation of protein import into nucleus; ureteric bud branching; hindgut morphogenesis; positive regulation of neuron differentiation; lung development; negative regulation of alpha-beta T cell differentiation; negative regulation of Wnt receptor signaling pathway; anatomical structure development; heart development; multicellular organismal development; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; Wnt receptor signaling pathway through beta-catenin; proteolysis; anterior/posterior pattern formation; positive regulation of T cell differentiation in the thymus; hair follicle development; cell-cell signaling; embryonic digestive tract morphogenesis; midbrain development; ectoderm development; positive regulation of smoothened signaling pathway; positive regulation of oligodendrocyte differentiation; oligodendrocyte development; activation of hh target transcription factor; striated muscle development; digestive tract morphogenesis; endocytosis; positive regulation of skeletal muscle development; negative thymic T cell selection; patterning of blood vessels; branching morphogenesis of a tube; polarity specification of anterior/posterior axis; positive regulation of cell differentiation; metanephros development; tongue development; apoptosis; cell fate specification; embryonic hindlimb morphogenesis; odontogenesis; vasculature development; regulation of transcription, DNA-dependent; male genitalia morphogenesis; cell communication; response to axon injury; positive regulation of Wnt receptor signaling pathway; dorsoventral neural tube patterning; organ formation; smoothened signaling pathway; hair follicle morphogenesis; thymus development; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; respiratory tube development; positive regulation of immature T cell proliferation in the thymus; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; formation of anatomical boundary; myoblast differentiation; limb bud formation; establishment of cell polarity; neuroblast proliferation; blood coagulation; cell development; positive regulation of alpha-beta T cell differentiation