Human ACE2 cDNA Clone Expression Plasmid – Cat# MBS1267807

ACE2 cDNA Clone – Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (Human)

Name: ACE2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267807
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267807

MBS1267807 is a cDNA clone targeting ACE2. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACE2, cDNA Clone

Full Product Name

ACE2 cDNA Clone

Product Gene Name

ACE2 cdna clone

Sequence

ATGTCAAGCT CTTCCTGGCT CCTTCTCAGC CTTGTTGCTG TAACTGCTGC TCAGTCCACC ATTGAGGAAC AGGCCAAGAC ATTTTTGGAC AAGTTTAACC ACGAAGCCGA AGACCTGTTC TATCAAAGTT CACTTGCTTC TTGGAATTAT AACACCAATA TTACTGAAGA GAATGTCCAA AACATGAATA ATGCTGGGGA CAAATGGTCT GCCTTTTTAA AGGAACAGTC CACACTTGCC CAAATGTATC CACTACAAGA AATTCAGAAT CTCACAGTCA AGCTTCAGCT GCAGGCTCTT CAGCAAAATG GGTCTTCAGT GCTCTCAGAA GACAAGAGCA AACGGTTGAA CACAATTCTA AATACAATGA GCACCATCTA CAGTACTGGA AAAGTTTGTA ACCCAGATAA TCCACAAGAA TGCTTATTAC TTGAACCAGG TTTGAATGAA ATAATGGCAA ACAGTTTAGA CTACAATGAG AGGCTCTGGG CTTGGGAAAG CTGGAGATCT GAGGTCGGCA AGCAGCTGAG GCCATTATAT GAAGAGTATG TGGTCTTGAA AAATGAGATG GCAAGAGCAA ATCATTATGA GGACTATGGG GATTATTGGA GAGGAGACTA TGAAGTAAAT GGGGTAGATG GCTATGACTA CAGCCGCGGC CAGTTGATTG AAGATGTGGA ACATACCTTT GAAGAGATTA AACCATTATA TGAACATCTT CATGCCTATG TGAGGGCAAA GTTGATGAAT GCCTATCCTT CCTATATCAG TCCAATTGGA TGCCTCCCTG CTCATTTGCT TGGTGATATG TGGGGTAGAT TTTGGACAAA TCTGTACTCT TTGACAGTTC CCTTTGGACA GAAACCAAAC ATAGATGTTA CTGATGCAAT GGTGGACCAG GCCTGGGATG CACAGAGAAT ATTCAAGGAG GCCGAGAAGT TCTTTGTATC TGTTGGTCTT CCTAATATGA CTCAAGGATT CTGGGAAAAT TCCATGCTAA CGGACCCAGG AAATGTTCAG AAAGCAGTCT GCCATCCCAC AGCTTGGGAC CTGGGGAAGG GCGACTTCAG GATCCTTATG TGCACAAAGG TGACAATGGA CGACTTCCTG ACAGCTCATC ATGAGATGGG GCATATCCAG TATGATATGG CATATGCTGC ACAACCTTTT CTGCTAAGAA ATGGAGCTAA TGAAGGATTC CATGAAGCTG TTGGGGAAAT CATGTCACTT TCTGCAGCCA CACCTAAGCA TTTAAAATCC ATTGGTCTTC TGTCACCCGA TTTTCAAGAA GACAATGAAA CAGAAATAAA CTTCCTGCTC AAACAAGCAC TCACGATTGT TGGGACTCTG CCATTTACTT ACATGTTAGA GAAGTGGAGG TGGATGGTCT TTAAAGGGGA AATTCCCAAA GACCAGTGGA TGAAAAAGTG GTGGGAGATG AAGCGAGAGA TAGTTGGGGT GGTGGAACCT GTGCCCCATG ATGAAACATA CTGTGACCCC GCATCTCTGT TCCATGTTTC TAATGATTAC TCATTCATTC GATATTACAC AAGGACCCTT TACCAATTCC AGTTTCAAGA AGCACTTTGT CAAGCAGCTA AACATGAAGG CCCTCTGCAC AAATGTGACA TCTCAAACTC TACAGAAGCT GGACAGAAAC TGTTCAATAT GCTGAGGCTT GGAAAATCAG AACCCTGGAC CCTAGCATTG GAAAATGTTG TAGGAGCAAA GAACATGAAT GTAAGGCCAC TGCTCAACTA CTTTGAGCCC TTATTTACCT GGCTGAAAGA CCAGAACAAG AATTCTTTTG TGGGATGGAG TACCGACTGG AGTCCATATG CAGACCAAAG CATCAAAGTG AGGATAAGCC TAAAATCAGC TCTTGGAGAT AAAGCATATG AATGGAACGA CAATGAAATG TACCTGTTCC GATCATCTGT TGCATATGCT ATGAGGCAGT ACTTTTTAAA AGTAAAAAAT CAGATGATTC TTTTTGGGGA GGAGGATGTG CGAGTGGCTA ATTTGAAACC AAGAATCTCC TTTAATTTCT TTGTCACTGC ACCTAAAAAT GTGTCTGATA TCATTCCTAG AACTGAAGTT GAAAAGGCCA TCAGGATGTC CCGGAGCCGT ATCAATGATG CTTTCCGTCT GAATGACAAC AGCCTAGAGT TTCTGGGGAT ACAGCCAACA CTTGGACCTC CTAACCAGCC CCCTGTTTCC ATATGGCTGA TTGTTTTTGG AGTTGTGATG GGAGTGATAG TGGTTGGCAT TGTCATCCTG ATCTTCACTG GGATCAGAGA TCGGAAGAAG AAAAATAAAG CAAGAAGTGG AGAAAATCCT TATGCCTCCA TCGATATTAG CAAAGGAGAA AATAATCCAG GATTCCAAAA CACTGATGAT GTTCAGACCT CCTTTTAG

Molecular Weight

63,912 Da

OMIM

300335

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ACE2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACE2. It may not necessarily be applicable to this product.

NCBI GI #

25140225

NCBI GeneID

59272

NCBI Accession #

BC039902

UniProt Secondary Accession #

Q6UWP0; Q86WT0; Q9NRA7; Q9UFZ6; C7ECU1

UniProt Related Accession #

Q9BYF1

NCBI Official Full Name

Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA

NCBI Official Synonym Full Names

angiotensin I converting enzyme 2

NCBI Official Symbol

ACE2

NCBI Official Synonym Symbols

ACEH

UniProt Protein Name

Angiotensin-converting enzyme 2

UniProt Synonym Protein Names

ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH

Protein Family

Angiotensin-converting enzyme

UniProt Gene Name

ACE2

UniProt Synonym Gene Names

ACEH

UniProt Entry Name

ACE2_HUMAN

NCBI Protein Information

angiotensin-converting enzyme 2

NCBI Summary for ACE2

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

UniProt Comments for ACE2

ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.17.23; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: cell surface; extracellular region; extracellular space; lipid raft; plasma membrane

Molecular Function: carboxypeptidase activity; endopeptidase activity; glycoprotein binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidyl-dipeptidase activity; protein binding; viral receptor activity; zinc ion binding

Biological Process: angiotensin catabolic process in blood; angiotensin maturation; angiotensin mediated drinking behavior; entry of virus into host cell; receptor biosynthetic process; regulation of cell proliferation; regulation of cytokine production; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; virion attachment, binding of host cell surface receptor

Research Articles on ACE2

1. ACE and ACE2 expression at the mRNA and protein levels are significantly increased in the myocardium of patients with heart failure.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ACE2 cdna clone

Products by Pathway	Pathway Diagram
ACE Inhibitor Pathway antibodies	ACE Inhibitor Pathway Diagram
Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies	Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Peptide Hormone Metabolism Pathway antibodies	Peptide Hormone Metabolism Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram
Renin-angiotensin System Pathway antibodies	Renin-angiotensin System Pathway Diagram
Renin-angiotensin System Pathway antibodies	Renin-angiotensin System Pathway Diagram

Diseases associated with ACE2 cdna clone

Disease Name	Pubmed Publications
Hypertension Antibodies	>255 publications with ACE2 and Hypertension
Vascular Diseases Antibodies	>192 publications with ACE2 and Vascular Diseases
Heart Diseases Antibodies	>129 publications with ACE2 and Heart Diseases
Kidney Diseases Antibodies	>92 publications with ACE2 and Kidney Diseases
Fibrosis Antibodies	>72 publications with ACE2 and Fibrosis
Hypertrophy Antibodies	>70 publications with ACE2 and Hypertrophy
Hypertension, Renal Antibodies	>67 publications with ACE2 and Hypertension, Renal
Heart Failure Antibodies	>61 publications with ACE2 and Heart Failure
Inflammation Antibodies	>47 publications with ACE2 and Inflammation
Cardiomegaly Antibodies	>36 publications with ACE2 and Cardiomegaly

Organs/Tissues associated with ACE2 cdna clone

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>207 publications with ACE2 and Kidney
Muscle Antibodies	>123 publications with ACE2 and Muscle
Brain Antibodies	>62 publications with ACE2 and Brain
Intestine Antibodies	>18 publications with ACE2 and Intestine
Placenta Antibodies	>14 publications with ACE2 and Placenta
Testis Antibodies	>11 publications with ACE2 and Testis
Mixed Antibodies	>7 publications with ACE2 and Mixed
Eye Antibodies	>5 publications with ACE2 and Eye
Stomach Antibodies	>4 publications with ACE2 and Stomach
Mouth Antibodies	>1 publications with ACE2 and Mouth