CAB39 Antibody – Rabbit Polyclonal

This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause the autosomal recessive neurologic disorder hyperphosphatasia with mental retardation syndrome 4 (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

CAB39: a adaptor protein that, together with STRAD-alpha, forms a regulatory complex capable of stimulating the activity of LKB1. Interacts with Mst4, which plays an essential role in brush border formation in intestinal epithelial cells.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cytosol

Molecular Function: kinase binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity

Biological Process: activation of protein kinase activity; cell cycle arrest; peptidyl-serine phosphorylation; protein heterooligomerization