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PDE1B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540576

Affinity Purified Pan Phosphodiesterase 1B AntibodyCyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a… More details

$540 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PDE1B, Polyclonal Antibody
Full Product Name
PDE1B Antibody
Product Gene Name
anti-PDE1B antibody
Product Synonym Names
5''-cyclic nucleotide phosphodiesterase 1B; 63 kDa Cam PDE; Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B; PDE1B1; Cam PDE 1B; PDE1B; PDE1B1; PDES 1B; Phosphodiesterase 1B; Phosphodiesterase 1B calmodulin dependent antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.58ug/ul in antibody stabilization buffer (lot specific)
Specificity
This antibody does not cross-react with PDE1A or PDE1C or any known PDE family m ember. This antibody will label all PDE1B variants.
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: PDE1B (MBS540576)
Positive Control: PDE1B (MBS543063)
Antibody/Peptide Pairs
PDE1B peptide (MBS544166) is used for blocking the activity of PDE1B antibody (MBS540576)
Molecular Weight
Predicted: 65 kDa.
Immunogen
Synthetic peptide corresponding to unique amino acid sequence on PDE1B gene.
Molecular Function
Calmodulin-binding, cAMP, cGMP, Metal-binding
Structure
Homodimer
Subcellular Location
Cytoplasm

Product Categories/Family for anti-PDE1B antibody

Primary Antibodies; Signal Transduction; Second Messengers; cGMP; PDE1B Antibody
Applications Tested/Suitable for anti-PDE1B antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-PDE1B antibody
Confocal Microscopy||1:50-1:200
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:50-1:200
Immunofluorescence: 1:50-1:200
Immunohistochemistry: 1:50-1:200
Immunoprecipitation: 1:200
Western Blot: 1:500-1:1,000.
This antibody labels multiple bands in the 65-72 kDa range all believed to be various PDE1B variants.

Western Blot (WB) of anti-PDE1B antibody

Rabbit Anti-PDE1B Polyclonal Antibody – Cat# MBS540576

Immunohistochemistry (IHC) of anti-PDE1B antibody

Rabbit Anti-PDE1B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS540576

Other Notes

Small volumes of anti-PDE1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE1B purchase

MBS540576 is an antibody targeting PDE1B. Also known as PDE1B Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE1B. It may not necessarily be applicable to this product.

NCBI GI #
148671965
NCBI GeneID
18574
NCBI Accession #
EDL03912.1
UniProt Secondary Accession #
O35384
UniProt Related Accession #
Q01065
NCBI Official Full Name
phosphodiesterase 1B, Ca2+-calmodulin dependent, isoform CRA_b, partial
NCBI Official Synonym Full Names
phosphodiesterase 1B, Ca2+-calmodulin dependent
NCBI Official Symbol
Pde1b
NCBI Official Synonym Symbols
Pde1b1
UniProt Protein Name
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
UniProt Synonym Protein Names
63 kDa Cam-PDE
UniProt Gene Name
Pde1b
UniProt Synonym Gene Names
Pde1b1; Cam-PDE 1B
UniProt Entry Name
PDE1B_MOUSE
NCBI Protein Information
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

UniProt Comments for PDE1B

PDE1B: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.17; Phosphodiesterase; Apoptosis; Nucleotide Metabolism - purine

Cellular Component: cell soma; cytoplasm

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity

Biological Process: cAMP catabolic process; cGMP catabolic process; locomotory behavior; regulation of dopamine metabolic process; regulation of neurotransmitter levels; response to amphetamine; serotonin metabolic process; signal transduction; visual learning
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Research Articles on PDE1B

1. These results prove that the kinetic properties of PDE isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2+]i.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PDE1B antibody

 Products by Pathway  Pathway Diagram
 Ca-dependent Events Pathway antibodies  Ca-dependent Events Pathway Diagram
 CaM Pathway antibodies  CaM Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calmodulin Induced Events Pathway antibodies  Calmodulin Induced Events Pathway Diagram
 Cam-PDE 1 Activation Pathway antibodies  Cam-PDE 1 Activation Pathway Diagram
 DAG And IP3 Signaling Pathway antibodies  DAG And IP3 Signaling Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram

Diseases associated with anti-PDE1B antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with PDE1B and Nervous System Diseases
 Disease Models, Animal Antibodies  >5 publications with PDE1B and Disease Models, Animal
 Inflammation Antibodies  >5 publications with PDE1B and Inflammation
 Brain Diseases Antibodies  >3 publications with PDE1B and Brain Diseases
 Hypertension Antibodies  >2 publications with PDE1B and Hypertension
 Cognition Disorders Antibodies  >2 publications with PDE1B and Cognition Disorders
 Cardiovascular Diseases Antibodies  >2 publications with PDE1B and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with PDE1B and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >1 publications with PDE1B and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with PDE1B and Liver Diseases

Organs/Tissues associated with anti-PDE1B antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18 publications with PDE1B and Brain
 Blood Antibodies  >10 publications with PDE1B and Blood
 Heart Antibodies  >6 publications with PDE1B and Heart
 Lung Antibodies  >4 publications with PDE1B and Lung
 Eye Antibodies  >4 publications with PDE1B and Eye
 Testis Antibodies  >3 publications with PDE1B and Testis
 Embryonic Tissue Antibodies  >2 publications with PDE1B and Embryonic Tissue
 Liver Antibodies  >2 publications with PDE1B and Liver
 Spinal Cord Antibodies  >1 publications with PDE1B and Spinal Cord
 Ovary Antibodies  >1 publications with PDE1B and Ovary
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