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Cytokeratin 7 (KRT7) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540887

keratin, type II cytoskeletal 7 AntibodyServes to block interferon-dependent interphase and stimulates DNA synthesis.  Plays a role in the translational regulation of human papillomavirus type 16 E7 mRNA. More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cytokeratin 7 (KRT7), Polyclonal Antibody
Full Product Name
Cytokeratin 7 Antibody
Product Gene Name
Product Synonym Names
CK 7; Cytokeratin 7; D15Wsu77e; K2C7; K7; Keratin 55k type ii cytoskeletal; Keratin 7; Keratin simple epithelial type 1 k7; Keratin type II cytoskeletal 7; Keratin-7; KRT 7; Krt2-7; MGC11625; MGC129731; mgc3625; Sarcolectin; SCL; Type ii mesothelial keratin k7; Type-II keratin Kb7 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Concentration
0.64-0.72 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Molecular Weight
51,386 Da
OMIM
148059
3D Structure
ModBase 3D Structure for P08729
Immunogen
Synthetic peptide taken within amino acid region 10-60 on human keratin, type II cytoskeletal 7 protein.
Immunoglobulin
IgG
Expression
Expressed in cultured epidermal, bronchial and mesothelial cells.  Seen throughout the glandular cells at the junction of the stomac and esophagus; not present in the esophogus, colon, ectocervix and liver.
Molecular Function
Structural molelcule activity; Host-virus interaction
Structure
Heterotetramer of two type I and two type II keratins, interacts with eukaryotic translation initiator factor 3 subunit EIF3S10, HPV16 E7, and GPER1.
Subcellular Location
Cytoplasm
Applications Tested/Suitable for anti-KRT7 antibody
ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-KRT7 antibody
ELISA: 1:10,000
Immunocytochemistry: 1:100
Immunofluorescence: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:250

Western Blot (WB) of anti-KRT7 antibody

Rabbit Anti-KRT7 Polyclonal Antibody – Cat# MBS540887

Western Blot (WB) of anti-KRT7 antibody

Rabbit Anti-KRT7 Polyclonal Antibody, Western Blot (WB) – Cat# MBS540887

Immunohistochemistry (IHC) of anti-KRT7 antibody

Rabbit Anti-KRT7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS540887

Immunohistochemistry (IHC) of anti-KRT7 antibody

Rabbit Anti-KRT7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS540887

Other Notes

Small volumes of anti-KRT7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KRT7 purchase

MBS540887 is an antibody targeting KRT7. Also known as Cytokeratin 7 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT7. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
keratin, type II cytoskeletal 7
NCBI Official Synonym Full Names
keratin 7
NCBI Official Symbol
KRT7
NCBI Official Synonym Symbols
K7; CK7; SCL; K2C7
UniProt Protein Name
Keratin, type II cytoskeletal 7
UniProt Synonym Protein Names
Cytokeratin-7; CK-7; Keratin-7; K7; Sarcolectin; Type-II keratin Kb7
Protein Family
UniProt Gene Name
KRT7
UniProt Synonym Gene Names
SCL; CK-7; K7
UniProt Entry Name
K2C7_HUMAN
NCBI Protein Information
keratin, type II cytoskeletal 7

NCBI Summary for KRT7

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
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UniProt Comments for KRT7

K7: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytoplasm; intermediate filament; keratin filament; nucleus

Molecular Function: protein binding; structural molecule activity

Biological Process: viral reproduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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