Annexin A6 (ANXA6) Antibody – Rabbit Polyclonal

ANXA6: a calcium/phospholipid-binding protein that may associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Phosphorylated in response to growth factor stimulation. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Motility/polarity/chemotaxis; Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: apical plasma membrane; focal adhesion; late endosome membrane; lysosomal membrane; melanosome; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; protein complex; sarcolemma

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; cholesterol binding; GTP binding; ligand-gated ion channel activity; lipid binding; protein binding; protein complex binding; protein homodimerization activity

Biological Process: calcium ion transport; mitochondrial calcium ion homeostasis; protein homooligomerization; regulation of muscle contraction