Golgin A2 (GOLGA2) Antibody – Rabbit Polyclonal

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]

GM130: Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1. Belongs to the GOLGA2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cis-Golgi network; ER to Golgi transport vesicle; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi cis cisterna; Golgi membrane; microtubule; nucleus; spindle pole

Molecular Function: microtubule binding; protein binding; protein kinase binding; syntaxin binding

Biological Process: anaphase-promoting complex activation during mitotic cell cycle; asymmetric cell division; centrosome organization and biogenesis; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; microtubule nucleation; negative regulation of autophagy; negative regulation of protein binding; positive regulation of protein amino acid glycosylation; protein amino acid glycosylation; protein homotetramerization; spindle assembly