NPY5R Antibody – Rabbit Polyclonal

The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

NPY5R: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 4q31-q32

Cellular Component: cytoplasm; integral to plasma membrane; neuron projection; plasma membrane

Molecular Function: neuropeptide Y receptor activity; pancreatic polypeptide receptor activity; peptide YY receptor activity

Biological Process: cell surface receptor linked signal transduction; eating behavior; feeding behavior; G-protein coupled receptor protein signaling pathway; generation of ovulation cycle rhythm; negative regulation of apoptosis; negative regulation of glutamate secretion; negative regulation of synaptic transmission, GABAergic; neuropeptide signaling pathway; positive regulation of acute inflammatory response; positive regulation of smooth muscle cell proliferation; synaptic transmission