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CHRNA5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9409589

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate… More details

$320 / 0.05 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
CHRNA5, Polyclonal Antibody
Full Product Name
CHRNA5 Antibody
Product Gene Name
anti-CHRNA5 antibody
Product Synonym Names
LNCR2; CHRNA5
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous level of total CHRNA5 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
SDS-PAGE MW: 53KD
OMIM
118505
3D Structure
ModBase 3D Structure for P30532
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human CHRNA5.
Target Name
CHRNA5

Product Categories/Family for anti-CHRNA5 antibody

Total protein Ab
Applications Tested/Suitable for anti-CHRNA5 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CHRNA5 antibody
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100

Western Blot (WB) of anti-CHRNA5 antibody

Western blot analysis of extracts of mouse brain tissue cell lines, using CHRNA5 antibody.
Rabbit Anti-CHRNA5 Polyclonal Antibody – Cat# MBS9409589

Other Notes

Small volumes of anti-CHRNA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHRNA5 purchase

MBS9409589 is an antibody targeting CHRNA5. Also known as CHRNA5 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHRNA5. It may not necessarily be applicable to this product.

NCBI GI #
33589827
NCBI GeneID
1138
NCBI Accession #
NP_000736.2
UniProt Primary Accession #
P30532
UniProt Secondary Accession #
Q15824; Q99554
UniProt Related Accession #
P30532
GenBank Nucleotide #
NM_000745.3
NCBI Official Full Name
neuronal acetylcholine receptor subunit alpha-5 isoform 1
NCBI Official Synonym Full Names
cholinergic receptor, nicotinic, alpha 5 (neuronal)
NCBI Official Symbol
CHRNA5
NCBI Official Synonym Symbols
LNCR2
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-5
Protein Family
Neuronal acetylcholine receptor
UniProt Gene Name
CHRNA5
UniProt Synonym Gene Names
NACHRA5
UniProt Entry Name
ACHA5_HUMAN
NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-5

UniProt Comments for CHRNA5

nAChRA5: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 5/CHRNA5 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; cell junction

Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; behavioral response to nicotine; signal transduction; cation transport

Disease: Smoking As A Quantitative Trait Locus 3
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Research Articles on CHRNA5

1. Suggest no relationship between these smoking-related SNPs in the CHRNA5/A3/B4 gene cluster and psoriasis vulgaris in Chinese Han population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CHRNA5 antibody

 Reference Product  PubMed Publications
 CHRNA3 antibody  >145 publications with CHRNA5 and CHRNA3
 CHRNB4 antibody  >119 publications with CHRNA5 and CHRNB4
 CHRNA4 antibody  >18 publications with CHRNA5 and CHRNA4
 CHRNA7 antibody  >16 publications with CHRNA5 and CHRNA7
 CHRNA6 antibody  >15 publications with CHRNA5 and CHRNA6
 CHRNB2 antibody  >14 publications with CHRNA5 and CHRNB2
 PSMA4 antibody  >8 publications with CHRNA5 and PSMA4
 CHRNA2 antibody  >7 publications with CHRNA5 and CHRNA2
 CHRNB1 antibody  >4 publications with CHRNA5 and CHRNB1
 AGPHD1 antibody  >2 publications with CHRNA5 and AGPHD1

Pathways associated with anti-CHRNA5 antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Nicotine Activity On Dopaminergic Neurons Pathway antibodies  Nicotine Activity On Dopaminergic Neurons Pathway Diagram
 Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram

Diseases associated with anti-CHRNA5 antibody

 Disease Name  Pubmed Publications
 Substance-Related Disorders Antibodies  >100 publications with CHRNA5 and Substance-Related Disorders
 Tobacco Use Disorder Antibodies  >91 publications with CHRNA5 and Tobacco Use Disorder
 Lung Neoplasms Antibodies  >61 publications with CHRNA5 and Lung Neoplasms
 TOBACCO ADDICTION, SUSCEPTIBILITY TO Antibodies  >18 publications with CHRNA5 and TOBACCO ADDICTION, SUSCEPTIBILITY TO
 Nervous System Diseases Antibodies  >16 publications with CHRNA5 and Nervous System Diseases
 Alcoholism Antibodies  >14 publications with CHRNA5 and Alcoholism
 Cocaine-Related Disorders Antibodies  >9 publications with CHRNA5 and Cocaine-Related Disorders
 Seizures Antibodies  >5 publications with CHRNA5 and Seizures
 Cardiovascular Diseases Antibodies  >4 publications with CHRNA5 and Cardiovascular Diseases
 Pain Antibodies  >4 publications with CHRNA5 and Pain

Organs/Tissues associated with anti-CHRNA5 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >155 publications with CHRNA5 and Nerve
 Lung Antibodies  >97 publications with CHRNA5 and Lung
 Brain Antibodies  >59 publications with CHRNA5 and Brain
 Mixed Antibodies  >4 publications with CHRNA5 and Mixed
 Bladder Antibodies  >2 publications with CHRNA5 and Bladder
 Kidney Antibodies  >2 publications with CHRNA5 and Kidney
 Embryonic Tissue Antibodies  >2 publications with CHRNA5 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with CHRNA5 and Pancreas
 Mouth Antibodies  >1 publications with CHRNA5 and Mouth
 Stomach Antibodies  >1 publications with CHRNA5 and Stomach
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