ADCY3 Antibody – Rabbit Polyclonal

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

ADCY3: a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Involved in odorant detection (possibly) via modulation of intracellular cAMP concentration.

Protein type: Lyase; EC 4.6.1.1; Adenylyl cyclase; Membrane protein, integral; Nucleotide Metabolism - purine; Transporter, aquaporin family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cilium; cytoplasm; Golgi apparatus; integral to membrane; integral to plasma membrane; lipid raft; membrane; nucleus; plasma membrane

Molecular Function: adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; metal ion binding

Biological Process: acrosome reaction; activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; female meiosis; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; olfactory learning; renal water homeostasis; sensory perception of smell; signal transduction; single fertilization; sperm motility