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PDE7A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS543561

BIOTIN-Conjugated cAMP-specific cyclic nucleotide phosphodiesterase PDE7A3 AntibodyHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PDE7A, Polyclonal Antibody
Full Product Name
PDE7A Antibody BIOTIN-Conjugated
Product Gene Name
Product Synonym Names
HCP 1; P2A; PDE 7; PDE 7A; PDE1/PDE2 yeast human complement of; Phosphodiesterase 7A; Phosphodiesterase isozyme 7; Rolipram insensitive phosphodiesterase type 7; TM22 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.5 ug/ul in antibody stabilization buffer (lot specific)
Specificity
This antibody is specific for PDE7A variants and will not cross-react with PDE7B or other PDE family members.
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: PDE7A (MBS543561)
Positive Control: PDE7A (MBS543099)
Antibody/Peptide Pairs
PDE7A peptide (MBS544224) is used for blocking the activity of PDE7A antibody (MBS543561)
Molecular Weight
48,828 Da
OMIM
171885
3D Structure
ModBase 3D Structure for Q13946
Immunogen
Synthetic cyclic peptide common to all PDE7A variants.
Expression
PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
Molecular Function
3', 5' -cyclic-AMP phosphodiesterase activity
Structure
Interacts with CBFA2T3
Subcellular Location
Isoform PDE7A1 : Cytoplasm degree cytosol, Isoform PDE7A2: Cytoplasm
Applications Tested/Suitable for anti-PDE7A antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-PDE7A antibody
Confocal Microscopy||1:100-1:250
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:100-1:250
Immunofluorescence: 1:100-1:250
Immunohistochemistry: 1:100-1:250
Immunoprecipitation: 1:250
Western Blot: 1:500

Other Notes

Small volumes of anti-PDE7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE7A purchase

MBS543561 is an antibody targeting PDE7A. Also known as PDE7A Antibody BIOTIN-Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE7A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cAMP-specific cyclic nucleotide phosphodiesterase PDE7A3
NCBI Official Synonym Full Names
phosphodiesterase 7A
NCBI Official Symbol
PDE7A
NCBI Official Synonym Symbols
HCP1; PDE7
UniProt Protein Name
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
UniProt Synonym Protein Names
HCP1; TM22
UniProt Gene Name
PDE7A
UniProt Entry Name
PDE7A_HUMAN
NCBI Protein Information
high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

NCBI Summary for PDE7A

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
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UniProt Comments for PDE7A

PDE7A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.53

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding

Biological Process: cAMP catabolic process; cAMP-mediated signaling
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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