PNPLA3 Antibody – Rabbit Polyclonal

PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.3; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Phospholipase; Lipid Metabolism - glycerolipid; Membrane protein, integral; Lipid Metabolism - glycerophospholipid; Transferase; Secondary Metabolites Metabolism - limonene and pinene degradation

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function: acylglycerol O-acyltransferase activity; diolein transacylation activity; lipoprotein lipase activity; mono-olein transacylation activity; phospholipase A2 activity; triacylglycerol lipase activity

Biological Process: triacylglycerol biosynthetic process; triacylglycerol catabolic process