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Phospho-PDE3B (PDE3B) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544181

BIOTIN-Conjugated Phosphorylated Phosphodiesterase 3B Antibody N-epitopeCyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in… More details

$680 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Phospho-PDE3B, Polyclonal Antibody
Full Product Name
Phospho PDE3B Antibody BIOTIN-Conjugated
Product Gene Name
anti-PDE3B antibody
Product Synonym Names
5''-cyclic phosphodiesterase B; Adipocyte cAMP phosphodiesterase cGMP inhibited; AI847709; cAMP Phosphodiesterase, adipocyte, cGMP-inhibited; CGI-PDE B; CGIP1; CGIPDE1; cGMP inhibited 3 5 cyclic phosphodiesterase B; HcGIP1; Pde3b; Phosphodiesterase 3B cGMP inhibited antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Chicken, Human, Monkey, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
1.0-1.25 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
Phospho-PDE3B peptide (MBS544310) is used for blocking the activity of Phospho-PDE3B antibody (MBS544181)
Molecular Weight
123,107 Da
Immunogen
Synthetic peptide taken within amino acid region 260-310 on rat PDE3B protein. Selective for only PDE3B variant
Expression
Abundant in adipose tissues.
Modification
Phosphorylated
Determinant
N-epitope
Molecular Function
Hydrolase, 3', 5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Structure
Interacts with PIK3CG. Interacts with RAPGEF3 and PIK3R6 (By similarity).
Subcellular Location
Membrane; Multipass membrane protein
Applications Tested/Suitable for anti-PDE3B antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-PDE3B antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500

Other Notes

Small volumes of anti-PDE3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE3B purchase

MBS544181 is an antibody targeting PDE3B. Also known as Phospho PDE3B Antibody BIOTIN-Conjugated. Reactive in Chicken, Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE3B. It may not necessarily be applicable to this product.

NCBI GI #
149068220
NCBI GeneID
29516
NCBI Accession #
EDM17772.1
UniProt Related Accession #
Q63085
NCBI Official Full Name
phosphodiesterase 3B, isoform CRA_a
NCBI Official Synonym Full Names
phosphodiesterase 3B
NCBI Official Symbol
Pde3b
UniProt Protein Name
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
UniProt Synonym Protein Names
CGIPDE1; Cyclic GMP-inhibited phosphodiesterase B; CGI-PDE B
Protein Family
cGMP-inhibited 3',5'-cyclic phosphodiesterase
UniProt Gene Name
Pde3b
UniProt Synonym Gene Names
CGI-PDE B
UniProt Entry Name
PDE3B_RAT
NCBI Protein Information
cGMP-inhibited 3',5'-cyclic phosphodiesterase B

NCBI Summary for PDE3B

catalyzes the hydrolysis of cAMP and cGMP; regulates insulin secretory processes [RGD, Feb 2006]

UniProt Comments for PDE3B

PDE3B: a cGMP-inhibited phosphodiesterase 1 involved in fat metabolism. Inhibition of PDE3B can augment PDE4 inhibitor-induced apoptosis in some patients with chronic lymphocytic leukemia.

Protein type: Membrane protein, multi-pass; EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase; Membrane protein, integral

Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membrane; membrane

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; phosphoprotein binding; protein kinase B binding

Biological Process: angiogenesis; cAMP catabolic process; cellular response to insulin stimulus; diterpenoid metabolic process; endocrine pancreas development; glucose homeostasis; negative regulation of angiogenesis; negative regulation of cell adhesion; negative regulation of insulin secretion; negative regulation of lipid catabolic process; regulation of insulin secretion; signal transduction
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Research Articles on PDE3B

1. C-peptide has the potential to act, conditionally, as an antilipolytic hormone by activating phosphodiesterase-3B.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PDE3B antibody

 Products by Pathway  Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Triggered By IGF1R Pathway antibodies  IRS-related Events Triggered By IGF1R Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram

Diseases associated with anti-PDE3B antibody

 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >17 publications with PDE3B and Diabetes Mellitus
 Cardiovascular Diseases Antibodies  >14 publications with PDE3B and Cardiovascular Diseases
 Necrosis Antibodies  >12 publications with PDE3B and Necrosis
 Disease Models, Animal Antibodies  >11 publications with PDE3B and Disease Models, Animal
 Fatty Liver Antibodies  >7 publications with PDE3B and Fatty Liver
 Heart Diseases Antibodies  >6 publications with PDE3B and Heart Diseases
 Inflammation Antibodies  >6 publications with PDE3B and Inflammation
 Lung Diseases Antibodies  >5 publications with PDE3B and Lung Diseases
 Hypertension Antibodies  >4 publications with PDE3B and Hypertension
 Brain Diseases Antibodies  >3 publications with PDE3B and Brain Diseases

Organs/Tissues associated with anti-PDE3B antibody

 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >34 publications with PDE3B and Adipose Tissue
 Heart Antibodies  >34 publications with PDE3B and Heart
 Lung Antibodies  >12 publications with PDE3B and Lung
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