Rabbit Anti-RASGRF2 Polyclonal Antibody – Cat# MBS544685

RASGRF2 Antibody – Rabbit Polyclonal

Name: RASGRF2 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS544685
Price: 610 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544685

BIOTIN-Conjugated Ras-specific guanine nucleotide-releasing factor 2 AntibodyFunctions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared… More details

$610 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RASGRF2, Polyclonal Antibody

Full Product Name

RASGRF2 Antibody BIOTIN-Conjugated

Product Gene Name

anti-RASGRF2 antibody

Product Synonym Names

GRF2; Ras guanine nucleotide exchange factor 2; Ras-GRF2 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

BIOTIN-Conjugated

Concentration

0.58 ug/ul in antibody stabilization buffer (lot specific)

Preparation and Storage

-20 degree C for long term storage

Matching Pairs

Antibody: RASGRF2 (MBS544685)
Positive Control: RASGRF2 (MBS543189)

Antibody/Peptide Pairs

RASGRF2 peptide (MBS544356) is used for blocking the activity of RASGRF2 antibody (MBS544685)

Molecular Weight

140,764 Da

OMIM

606614

3D Structure

ModBase 3D Structure for O14827

Immunogen

Synthetic peptide taken within amino acid region 1100-1200 on human RASGRF2 protein.

Expression

Widely expressed with higher expression in the brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).

Molecular Function

Guanine-nucleotide releasing factor, Rho guayl-nucleotide exchange factor activity

Structure

Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1. Interacts in a calcium-dependent manner with calmodulin (by similarity).

Subcellular Location

Cytoplasm, Cell membrane; Peripheral membrane protein, Endoplasmic Reticulum membrane; Peripheral membrane protein

Applications Tested/Suitable for anti-RASGRF2 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-RASGRF2 antibody

Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Other Notes

Small volumes of anti-RASGRF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RASGRF2 purchase

MBS544685 is an antibody targeting RASGRF2. Also known as RASGRF2 Antibody BIOTIN-Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RASGRF2. It may not necessarily be applicable to this product.

NCBI GI #

162416200

NCBI GeneID

5924

NCBI Accession #

O14827.2

UniProt Primary Accession #

O14827

UniProt Secondary Accession #

Q9UK56; B9EG89

UniProt Related Accession #

O14827

NCBI Official Full Name

Ras-specific guanine nucleotide-releasing factor 2

NCBI Official Synonym Full Names

Ras protein specific guanine nucleotide releasing factor 2

NCBI Official Symbol

RASGRF2

NCBI Official Synonym Symbols

GRF2; RAS-GRF2

UniProt Protein Name

Ras-specific guanine nucleotide-releasing factor 2

UniProt Synonym Protein Names

Ras guanine nucleotide exchange factor 2

Protein Family

Ras-specific guanine nucleotide-releasing factor

UniProt Gene Name

RASGRF2

UniProt Synonym Gene Names

GRF2; Ras-GRF2

UniProt Entry Name

RGRF2_HUMAN

NCBI Protein Information

ras-specific guanine nucleotide-releasing factor 2

NCBI Summary for RASGRF2

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

UniProt Comments for RASGRF2

RASGRF2: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.

Protein type: GEFs, Ras; GEFs

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: cytosol; endoplasmic reticulum membrane; plasma membrane

Molecular Function: calmodulin binding; guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: MAPKKK cascade; positive regulation of apoptosis; positive regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction

Research Articles on RASGRF2

1. these results suggest that betaarrestin1 regulates rasgrf2 gene expression and Rac activation to affect membrane protrusion and cell migration and invasion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RASGRF2 antibody

Reference Product	PubMed Publications
CDC42 antibody	>6 publications with RASGRF2 and CDC42
RAC1 antibody	>4 publications with RASGRF2 and RAC1
HRAS antibody	>1 publications with RASGRF2 and HRAS

Pathways associated with anti-RASGRF2 antibody

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies	Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
CREB Phosphorylation Through The Activation Of Ras Pathway antibodies	CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram

Diseases associated with anti-RASGRF2 antibody

Disease Name	Pubmed Publications
Cell Transformation, Neoplastic Antibodies	>2 publications with RASGRF2 and Cell Transformation, Neoplastic
Disease Models, Animal Antibodies	>2 publications with RASGRF2 and Disease Models, Animal
Mammary Neoplasms, Experimental Antibodies	>2 publications with RASGRF2 and Mammary Neoplasms, Experimental
Lung Neoplasms Antibodies	>2 publications with RASGRF2 and Lung Neoplasms
Carcinoma Antibodies	>2 publications with RASGRF2 and Carcinoma
Mammary Neoplasms, Animal Antibodies	>2 publications with RASGRF2 and Mammary Neoplasms, Animal
Prostatic Diseases Antibodies	>1 publications with RASGRF2 and Prostatic Diseases
Neoplasm Metastasis Antibodies	>1 publications with RASGRF2 and Neoplasm Metastasis
Weight Loss Antibodies	>1 publications with RASGRF2 and Weight Loss
Inflammation Antibodies	>1 publications with RASGRF2 and Inflammation

Organs/Tissues associated with anti-RASGRF2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>16 publications with RASGRF2 and Brain
Lung Antibodies	>3 publications with RASGRF2 and Lung
Muscle Antibodies	>2 publications with RASGRF2 and Muscle
Spleen Antibodies	>2 publications with RASGRF2 and Spleen
Embryonic Tissue Antibodies	>1 publications with RASGRF2 and Embryonic Tissue
Prostate Antibodies	>1 publications with RASGRF2 and Prostate
Kidney Antibodies	>1 publications with RASGRF2 and Kidney