Human IL21 Active Protein – Cat# MBS546071

Interleukin-21 (IL21) Human Active Protein

Name: IL21 Active Protein; Interleukin-21; Human; MyBioSource
Brand: MyBioSource
SKU: MBS546071
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546071

IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Interleukin-21 (Il21), Active Protein

Full Product Name

Recombinant Human Interleukin-21; human IL-21

Product Gene Name

Il21 active protein

Product Synonym Names

Interleukin-21; human IL-21; Human Interleukin-21

Host

E Coli

Form/Format

Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

>97% by SDS-PAGE and HPLC analyses.

Preparation and Storage

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles

Molecular Weight

16,811 Da

Chromosome Location

Chromosome: 3; NC_000069.6 (37222759..37232618, complement). Location: 3 B; 3

3D Structure

ModBase 3D Structure for Q9ES17

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Molecular Weight Information

Approximately 15.0 KDa, a single non-glycosylated polypeptide chain containing 132 amino acids.

Biological Activity

Determined by its ability to proliferate activated B cells.

Endotoxin Level

Less than 1EU/mg of rHuIL-21 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.

Other Notes

Small volumes of Il21 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Il21 purchase

MBS546071 is an active protein targeting Il21. Also known as Recombinant Human Interleukin-21; human IL-21. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Il21. It may not necessarily be applicable to this product.

NCBI GI #

11140821

NCBI GeneID

60505

NCBI Accession #

NP_068554.1

UniProt Primary Accession #

Q9ES17

UniProt Related Accession #

Q9ES17

GenBank Nucleotide #

NM_021782.2

NCBI Official Full Name

interleukin-21

NCBI Official Synonym Full Names

interleukin 21

NCBI Official Symbol

Il21

UniProt Protein Name

Interleukin-21

Protein Family

Interleukin

UniProt Gene Name

Il21

UniProt Synonym Gene Names

IL-21

UniProt Entry Name

IL21_MOUSE

NCBI Protein Information

interleukin-21; IL-21

UniProt Comments for Il21

IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cell development/differentiation; Cytokine; Apoptosis; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding; cytokine activity

Biological Process: positive regulation of interleukin-17 production; positive regulation of natural killer cell cytokine production; cell maturation; B cell apoptosis; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of interleukin-10 production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of cell proliferation; positive regulation of B cell proliferation; positive regulation of B cell differentiation; immune response; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process

Research Articles on Il21

1. Notably, Th17 differentiation in the absence of NR4A2 was restored by exogenous IL-21, indicating that NR4A2 controls full maturation of Th17 cells via autocrine IL-21 signalling

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Il21 active protein

Reference Product	PubMed Publications
Il21r active protein	>316 publications with Il21 and Il21r
Stat3 active protein	>101 publications with Il21 and Stat3
Il15 active protein	>73 publications with Il21 and Il15
Cxcr5 active protein	>48 publications with Il21 and Cxcr5
Il23r active protein	>12 publications with Il21 and Il23r
Il7 active protein	>3 publications with Il21 and Il7
Ifng active protein	>2 publications with Il21 and Ifng
Il9 active protein	>2 publications with Il21 and Il9

Pathways associated with Il21 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with Il21 active protein

Disease Name	Pubmed Publications
Autoimmune Diseases Antibodies	>211 publications with Il21 and Autoimmune Diseases
Inflammation Antibodies	>135 publications with Il21 and Inflammation
Skin Diseases Antibodies	>58 publications with Il21 and Skin Diseases
Lupus Erythematosus, Systemic Antibodies	>54 publications with Il21 and Lupus Erythematosus, Systemic
Necrosis Antibodies	>51 publications with Il21 and Necrosis
Celiac Disease Antibodies	>30 publications with Il21 and Celiac Disease
Liver Diseases Antibodies	>29 publications with Il21 and Liver Diseases
Hepatitis Antibodies	>28 publications with Il21 and Hepatitis
Kidney Diseases Antibodies	>24 publications with Il21 and Kidney Diseases
Hypersensitivity Antibodies	>22 publications with Il21 and Hypersensitivity

Organs/Tissues associated with Il21 active protein

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>62 publications with Il21 and Spleen
Thymus Antibodies	>7 publications with Il21 and Thymus