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IL-3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS551043

IL3 is produced mainly by T- cells following cell activation by antigens and mitogens, but also by keratinocytes, NK-cells, mast cells, endothelial cells, and monocytes. The analysis of bacterial- derived recombinant IL3 shows that glycosylation is not… More details

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Product Overview

Product Name
IL-3, Polyclonal Antibody
Full Product Name
Rabbit anti IL-3 Polyclonal
Product Gene Name
anti-IL-3 antibody
Product Synonym Names
Rabbit anti IL-3 Polyclonal purified; T-cell growth factor; tcgf; aldesleukin; il3; il-3; polyclonal; pab
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
Purity/Purification
Serum IgG fraction was purified by Protein G affinity chromatography.
Preparation and Storage
The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
Molecular Weight
17,233 Da
OMIM
147740
3D Structure
ModBase 3D Structure for P08700
Source Note
Polyclonal Interleukin-3 antibody was produced from sera of rabbits immunized with synthetic protein containing Interleukin-3 antigenic determinants.
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers

Product Categories/Family for anti-IL-3 antibody

Polyclonal
Applications Tested/Suitable for anti-IL-3 antibody
Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)
Application Notes for anti-IL-3 antibody
ELISA: Use at a concentration range of 1-2ug/ml.
Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.

Other Notes

Small volumes of anti-IL-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-3 purchase

MBS551043 is an antibody targeting IL-3. Also known as Rabbit anti IL-3 Polyclonal. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-3. It may not necessarily be applicable to this product.

NCBI GI #
28416915
NCBI GeneID
3562
NCBI Accession #
NP_000579.2
UniProt Primary Accession #
P08700
UniProt Secondary Accession #
Q6GS87
UniProt Related Accession #
P08700; Q6NZ78; Q6NZ79
GenBank Nucleotide #
NM_000588.3
NCBI Official Full Name
interleukin-3
UniProt Protein Name
Interleukin-3
UniProt Synonym Protein Names
Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor
UniProt Gene Name
IL3
UniProt Synonym Gene Names
IL-3; MCGF
UniProt Entry Name
IL3_HUMAN

NCBI Summary for IL-3

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL-3

IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.

Protein type: Secreted, signal peptide; Cytokine; Apoptosis; Oncoprotein; Secreted; Cell cycle regulation

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-3 receptor binding; growth factor activity; cytokine activity

Biological Process: nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of tyrosine phosphorylation of Stat5 protein; embryonic hemopoiesis; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of DNA replication
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL-3 antibody

 Reference Product  PubMed Publications
 CSF2RB antibody  >10 publications with IL-3 and CSF2RB
 IL3RA antibody  >6 publications with IL-3 and IL3RA
 PIK3CD antibody  >1 publications with IL-3 and PIK3CD
 PIK3CA antibody  >1 publications with IL-3 and PIK3CA
 HRAS antibody  >1 publications with IL-3 and HRAS

Pathways associated with anti-IL-3 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram

Diseases associated with anti-IL-3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >115 publications with IL-3 and Neoplasms
 Leukemia Antibodies  >99 publications with IL-3 and Leukemia
 Leukemia, Myeloid Antibodies  >67 publications with IL-3 and Leukemia, Myeloid
 Hematologic Diseases Antibodies  >47 publications with IL-3 and Hematologic Diseases
 Leukemia, Myeloid, Acute Antibodies  >39 publications with IL-3 and Leukemia, Myeloid, Acute
 Bone Marrow Diseases Antibodies  >35 publications with IL-3 and Bone Marrow Diseases
 Hypersensitivity Antibodies  >21 publications with IL-3 and Hypersensitivity
 Lung Diseases Antibodies  >18 publications with IL-3 and Lung Diseases
 Neoplasms, Experimental Antibodies  >18 publications with IL-3 and Neoplasms, Experimental
 Drug Toxicity Antibodies  >17 publications with IL-3 and Drug Toxicity

Organs/Tissues associated with anti-IL-3 antibody

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >11 publications with IL-3 and Mixed
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