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Beta Defensin-1 (BD-1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553189

Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins, which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides.It is thought that… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
beta Defensin-1 (BD-1), Recombinant Protein
Full Product Name
Human beta Defensin-1 Recombinant
Product Gene Name
BD-1 recombinant protein
Product Synonym Names
bd1; bd-1; beta defensin; DEFB1
Sequence
MRTSYLLLFT LCLLLSEMAS GGNFLTGLGH RSDHYNCVSS GGQCLYSACP IFTKIQGTCY RGKAKCCK
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant Human beta Defensin-1 was lyophilized from 0.2 um filtered 100mM NaCl, 20mM PB, pH 7.4.
Purity/Purification
>98%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
7,420 Da
OMIM
602056
3D Structure
ModBase 3D Structure for P60022
Domain
Defensin
Host Note
Optimized DNA sequence encoding Human beta Defensin-1 mature chain was expressed in Escherichia Coli.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight Note
Native human BD-1 is generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 5 kDa. Recombinant beta Defensin-1 is a disulfide-linked monomer protein consisting of 47 amino acid residue subunits, and migrates as an approximately 5 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Product Categories/Family for BD-1 recombinant protein

Cytokines

Other Notes

Small volumes of BD-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BD-1 purchase

MBS553189 is a recombinant protein targeting BD-1. Also known as Human beta Defensin-1 Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for BD-1. It may not necessarily be applicable to this product.

NCBI GI #
4885181
NCBI GeneID
1672
NCBI Accession #
NP_005209.1
UniProt Primary Accession #
P60022
UniProt Secondary Accession #
Q09753
UniProt Related Accession #
P60022; Q86SQ8
GenBank Nucleotide #
NM_005218.3
NCBI Official Full Name
beta-defensin 1 preproprotein
UniProt Protein Name
Beta-defensin 1
UniProt Synonym Protein Names
Defensin, beta 1
Protein Family
Beta-defensin
UniProt Gene Name
DEFB1
UniProt Synonym Gene Names
BD1; HBD1; BD-1; hBD-1
UniProt Entry Name
DEFB1_HUMAN

NCBI Summary for BD-1

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for BD-1

defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; Golgi lumen; extracellular region

Biological Process: G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; innate immune response in mucosa; response to bacterium; antibacterial humoral response; innate immune response; immune response; response to testosterone stimulus; chemotaxis; acute inflammatory response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BD-1 recombinant protein

 Reference Product  PubMed Publications
 CCR6 recombinant protein  >3 publications with BD-1 and CCR6

Pathways associated with BD-1 recombinant protein

 Products by Pathway  Pathway Diagram
 Beta Defensins Pathway antibodies  Beta Defensins Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with BD-1 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >42 publications with BD-1 and Inflammation
 Neoplasms Antibodies  >28 publications with BD-1 and Neoplasms
 Lung Diseases Antibodies  >24 publications with BD-1 and Lung Diseases
 Carcinoma Antibodies  >19 publications with BD-1 and Carcinoma
 Fibrosis Antibodies  >18 publications with BD-1 and Fibrosis
 Skin Diseases Antibodies  >13 publications with BD-1 and Skin Diseases
 Adenocarcinoma Antibodies  >9 publications with BD-1 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >8 publications with BD-1 and Carcinoma, Squamous Cell
 Mouth Neoplasms Antibodies  >8 publications with BD-1 and Mouth Neoplasms
 Kidney Diseases Antibodies  >7 publications with BD-1 and Kidney Diseases

Organs/Tissues associated with BD-1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >35 publications with BD-1 and Skin
 Kidney Antibodies  >28 publications with BD-1 and Kidney
 Intestine Antibodies  >17 publications with BD-1 and Intestine
 Prostate Antibodies  >5 publications with BD-1 and Prostate
 Brain Antibodies  >4 publications with BD-1 and Brain
 Muscle Antibodies  >3 publications with BD-1 and Muscle
 Thyroid Antibodies  >2 publications with BD-1 and Thyroid
 Pancreas Antibodies  >2 publications with BD-1 and Pancreas
 Connective Tissue Antibodies  >1 publications with BD-1 and Connective Tissue
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